{"doi":"10.1002/acr.25295","title":"Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis","abstract":"OBJECTIVE: To assess how changes in depressive symptoms influence physical function over time among those with radiographic knee osteoarthritis (OA). METHODS: Participants from the Osteoarthritis Initiative with radiographic knee OA (n = 2,212) and complete data were identified at baseline. Depressive symptoms were assessed as a time-varying score at baseline and the first three annual follow-up visits using the Center for Epidemiological Studies Depression Scale (CES-D) Scale. Physical function was measured at the first four follow-up visits using 20-meter gait speed meters per second. The following two marginal structural models were fit: one assessing the main effect of depressive symptoms on gait speed and another assessing time-specific associations. RESULTS: Time-adjusted results indicated that higher CES-D scores were significantly associated with slower gait speed (-0.0048; 95% confidence interval -0.0082 to -0.0014), and time-specific associations of CES-D were largest during the first follow-up interval (-0.0082; 95% confidence interval -0.0128 to -0.0035). During subsequent follow-up time points, the influence of depressive symptoms on gait speed diminished. CONCLUSION: The negative effect of depressive symptoms on physical function may decrease over time as knee OA progresses.","journal":"Arthritis Care & Research","year":2024,"id":448202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7902,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":31642,"name":"Marc C. Hochberg","orcid":"0000-0001-7705-5593","position":1,"is_corresponding":false},{"id":36350,"name":"Michelle Shardell","orcid":"0000-0002-5283-2082","position":2,"is_corresponding":false},{"id":389916,"name":"Alice S. Ryan","orcid":"0000-0003-3708-110X","position":3,"is_corresponding":false},{"id":92359,"name":"Yu Dong","orcid":null,"position":4,"is_corresponding":false},{"id":409771,"name":"Brock A. Beamer","orcid":"0000-0002-6941-0898","position":5,"is_corresponding":false},{"id":1151352,"name":"Jason E. Peer","orcid":"0000-0003-2388-1202","position":6,"is_corresponding":false},{"id":287735,"name":"Elizabeth A. Stuart","orcid":"0000-0002-9042-8611","position":7,"is_corresponding":false},{"id":478451,"name":"Megan S. Schuler","orcid":"0000-0002-6009-8367","position":8,"is_corresponding":false},{"id":413538,"name":"Joseph J. Gallo","orcid":"0000-0002-7878-0321","position":9,"is_corresponding":false},{"id":478450,"name":"Alan M. Rathbun","orcid":"0000-0003-3611-5494","position":10,"is_corresponding":false},{"id":1151350,"name":"Rhea Mehta","orcid":"0000-0002-1580-3020","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"38200641","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}