{"doi":"10.1002/acr.25050","title":"Relation of Temporal Asymmetry During Walking to <scp>Two‐Year</scp> Knee Pain Outcomes in Those With <scp>Mild‐to‐Moderate</scp> Unilateral Knee Pain: An Exploratory Analysis From the Multicenter Osteoarthritis Study","abstract":"OBJECTIVE: We aimed to explore the cross-sectional relation of unilateral knee pain severity and temporal asymmetry during walking and to determine relations of temporal asymmetry during walking to 2-year changes in ipsilateral and contralateral knee pain in those with mild-to-moderate unilateral knee pain. METHODS: The Multicenter Osteoarthritis Study is a prospective cohort study of adults with or at risk for knee osteoarthritis. The current study included participants with unilateral knee pain. Gait was assessed during self-selected and fast walking at baseline. Knee pain was assessed at baseline and 2 years. We calculated limb symmetry indices (LSIs; nonpainful limb/painful limb × 100) for stance, single-limb support time, and double-limb support time, then examined their relations to unilateral knee pain severity, incident contralateral knee pain, and persistent ipsilateral knee pain. RESULTS: Unilateral knee pain severity was not associated with temporal asymmetry during self-selected or fast walking. At 2 years, 17.1% of participants had incident contralateral knee pain and 51.4% had persistent ipsilateral knee pain. For self-selected walking, greater LSIs (i.e., longer time on the nonpainful limb) for stance and single-limb support time were associated with decreased odds of incident contralateral knee pain. Measures of temporal asymmetry were not associated with persistent ipsilateral knee pain, except for single-limb support time during fast walking. CONCLUSION: For those with unilateral knee pain, temporal asymmetry during walking is not associated with pain severity. However, select measures of stance and single-limb support time during self-selected and fast walking relate to longitudinal knee pain outcomes.","journal":"Arthritis Care & Research","year":2022,"id":278190,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9652,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":31266,"name":"David T. Felson","orcid":"0000-0002-2668-2447","position":1,"is_corresponding":false},{"id":451657,"name":"Cara L. Lewis","orcid":"0000-0002-9888-4902","position":2,"is_corresponding":false},{"id":55625,"name":"Tuhina Neogi","orcid":"0000-0002-9515-1711","position":3,"is_corresponding":false},{"id":267434,"name":"Michael P. LaValley","orcid":"0000-0002-8488-5170","position":4,"is_corresponding":false},{"id":950765,"name":"K.D. Gross","orcid":null,"position":5,"is_corresponding":false},{"id":50681,"name":"Michael C. Nevitt","orcid":"0000-0002-6988-7530","position":6,"is_corresponding":false},{"id":245367,"name":"Cora E. Lewis","orcid":"0000-0002-2301-5796","position":7,"is_corresponding":false},{"id":332065,"name":"James C. Torner","orcid":"0000-0003-0979-4874","position":8,"is_corresponding":false},{"id":427721,"name":"Joshua J. Stefanik","orcid":"0000-0002-9250-2061","position":9,"is_corresponding":false},{"id":427717,"name":"Patrick Corrigan","orcid":"0000-0001-7263-5599","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T00:28:43.133347Z","pmid":"36305013","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}