{"doi":"10.1002/acn3.70237","title":"Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus","abstract":"OBJECTIVE: The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low-field MRI (LF-MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH. We sought to evaluate the feasibility of LF-MRI and apply a machine learning (ML) segmentation algorithm to examine atrophy and white matter hyperintensities (WMH) in PWH compared to people without HIV (PWoH) of similar age. METHODS: Individuals with a confirmed diagnosis of HIV on antiretroviral therapy underwent LF-MRI (64 mT) acquisition in the outpatient neurology clinic. PWoH with > 1 vascular comorbidity (VC cohort, n = 25) or with mild cognitive impairment (MCI cohort, n = 24) due to Alzheimer's disease served as comparators. LF-MRI brain region segmentations were derived using the ML algorithm WMH-SynthSeg in FreeSurfer. Brain regions corrected for intracranial volume were compared between cohorts after adjusting for age and sex. RESULTS: Thirty virally suppressed PWH were included. LF-MRI derived brain volumes from PWH demonstrated a reduction in volume of the caudate relative to PWoH with VC (p < 0.05). Volume of the putamen and white matter was reduced in PWH compared to VC (p < 0.05). Hippocampal volume was comparable between PWH and PWoH (p ≥ 0.05), while volume of the amygdala was reduced in those with MCI alone (p < 0.05). No differences in WMH were seen between these cohorts (p > 0.05). INTERPRETATION: LF-MRI is feasible in an outpatient setting, and ML algorithms enable detection of regional atrophy and WMH in PWH. LF-MRI may enable more frequent monitoring and earlier detection of atrophy in at-risk populations.","journal":"Annals of Clinical and Translational Neurology","year":2025,"id":580234,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1491038,"name":"Malachi Keo","orcid":"0009-0008-6288-7619","position":1,"is_corresponding":false},{"id":1161649,"name":"Jennifer D. Guo","orcid":"0009-0003-8438-2826","position":2,"is_corresponding":false},{"id":1491484,"name":"Daire Daly","orcid":null,"position":3,"is_corresponding":false},{"id":1491485,"name":"Richard Ahern","orcid":null,"position":4,"is_corresponding":false},{"id":731771,"name":"Kimon C. Zachary","orcid":null,"position":5,"is_corresponding":false},{"id":311026,"name":"Gregory K. Robbins","orcid":"0000-0001-7545-5817","position":6,"is_corresponding":false},{"id":88092,"name":"Rajesh T. Gandhi","orcid":"0000-0002-9701-6062","position":7,"is_corresponding":false},{"id":546053,"name":"Bragi Sveinsson","orcid":"0000-0001-8109-0404","position":8,"is_corresponding":false},{"id":421725,"name":"Adam de Havenon","orcid":"0000-0001-8178-8597","position":9,"is_corresponding":false},{"id":256547,"name":"Kevin N. Sheth","orcid":"0000-0003-2003-5473","position":10,"is_corresponding":false},{"id":226557,"name":"Otto Rapalino","orcid":"0000-0002-5038-4183","position":11,"is_corresponding":false},{"id":1491486,"name":"Juan Eugenio Iglesias Gonzales","orcid":null,"position":12,"is_corresponding":false},{"id":350022,"name":"W. Taylor Kimberly","orcid":"0000-0002-2519-8530","position":13,"is_corresponding":false},{"id":311025,"name":"Shibani S. Mukerji","orcid":"0000-0002-5677-6954","position":14,"is_corresponding":false},{"id":1018210,"name":"Annabel Sorby‐Adams","orcid":"0000-0003-1648-3898","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:38.868285Z","pmid":"41195659","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}