{"doi":"10.1002/acn3.631","title":"[\n                    <sup>18</sup>\n                    F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The\n                    <jats:styled-content style=\"fixed-case\">PET</jats:styled-content>\n                    ligand [\n                    <jats:sup>18</jats:sup>\n                    F]\n                    <jats:styled-content style=\"fixed-case\">AV</jats:styled-content>\n                    ‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with\n                    <jats:styled-content style=\"fixed-case\">TDP</jats:styled-content>\n                    ‐43 pathology. Here we assessed [\n                    <jats:sup>18</jats:sup>\n                    F]\n                    <jats:styled-content style=\"fixed-case\">AV</jats:styled-content>\n                    ‐1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by\n                    <jats:styled-content style=\"fixed-case\">TDP</jats:styled-content>\n                    ‐43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls.\n                  </jats:p>","journal":"Annals of Clinical and Translational Neurology","year":2018,"id":597912,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1531918,"name":"Thomas E. Cope","orcid":null,"position":1,"is_corresponding":false},{"id":1531919,"name":"Simon P. Jones","orcid":null,"position":2,"is_corresponding":false},{"id":317718,"name":"Luca Passamonti","orcid":"0000-0002-7937-0615","position":3,"is_corresponding":false},{"id":751548,"name":"Young T. Hong","orcid":null,"position":4,"is_corresponding":false},{"id":1531920,"name":"Tim Fryer","orcid":null,"position":5,"is_corresponding":false},{"id":1410970,"name":"Robert Arnold","orcid":"0000-0002-0524-9812","position":6,"is_corresponding":false},{"id":1531921,"name":"Jonathan P. Coles","orcid":null,"position":7,"is_corresponding":false},{"id":1531922,"name":"Franklin A. Aigbirhio","orcid":null,"position":8,"is_corresponding":false},{"id":860725,"name":"Karalyn Patterson","orcid":"0000-0003-1927-7424","position":9,"is_corresponding":false},{"id":1513461,"name":"John T. O'Brien","orcid":null,"position":10,"is_corresponding":false},{"id":271283,"name":"James B. Rowe","orcid":"0000-0001-7216-8679","position":11,"is_corresponding":false},{"id":1531917,"name":"Richard W. Bevan‐Jones","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"[\n                    <sup>18</sup>\n                    F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The\n                    <jats:styled-content style=\"fixed-case\">PET</jats:styled-content>\n                    ligand [\n                    <jats:sup>18</jats:sup>\n                    F]\n                    <jats:styled-content style=\"fixed-case\">AV</jats:styled-content>\n                    ‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with\n                    <jats:styled-content style=\"fixed-case\">TDP</jats:styled-content>\n                    ‐43 pathology. Here we assessed [\n                    <jats:sup>18</jats:sup>\n                    F]\n                    <jats:styled-content style=\"fixed-case\">AV</jats:styled-content>\n                    ‐1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by\n                    <jats:styled-content style=\"fixed-case\">TDP</jats:styled-content>\n                    ‐43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30349864","pmcid":"PMC6186940","openalex_id":"https://openalex.org/W2890242327","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"103838","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UU_00005/12","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/P01271X/1","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_U105597119","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/K02308X/1","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/M009041/1","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"ACF-2013-14-007","title":null},{"funder_name":"Wellcome Trust","grant_id":"103838/Z/14/Z","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"ACF-2011-01-002","title":null},{"funder_name":"Engineering and Physical Sciences Research Council","grant_id":"EP/P008224/1","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/M024873/1","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"","title":null},{"funder_name":"Patrick Berthoud Charitable Trust","grant_id":"","title":null}],"total_grants":13,"fwci":1.6374,"citation_percentile":0.83627204,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.631","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.631","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Facn3.631","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.631","host_type":"publisher"},{"url":"https://doi.org/10.1002/acn3.631","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30349864","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6186940","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6186940","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6186940?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Alzheimer's disease research and treatments","Cholinesterase and Neurodegenerative Diseases","Parkinson's Disease Mechanisms and Treatments"],"mesh_terms":[],"keywords":["C9orf72","Frontotemporal dementia","Medicine","Dementia","Frontotemporal lobar degeneration","Tau pathology","Semantic dementia","Trinucleotide repeat expansion","Neuroscience","Pathology","Alzheimer's disease","Disease","Genetics","Psychology","Biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T14:34:23.667711Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}