{"doi":"10.1002/acn3.52271","title":"Priming and task‐specific training for arm weakness post stroke: A randomized controlled trial","abstract":"OBJECTIVE: The objective of this work was to evaluate if task-specific training (TST) preceded by bilateral upper limb motor priming (BUMP) reduces upper limb impairment more than TST preceded by control priming ([CP], sham electrical stimulation) in people with chronic stroke. METHODS: In this single-blind, randomized controlled trial, 76 adults with moderate to severe upper limb hemiparesis ≥6 months post-stroke were stratified by baseline impairment and randomized to receive either BUMP or CP prior to receiving the same TST protocol. Participants completed 30 h of treatment in 15 days over 6 weeks. The primary outcome was change in Fugl-Meyer upper extremity (FMUE) from baseline to 8-week follow-up. We also report clinically meaningful response rates defined as a change in FMUE score of 6 points or greater. RESULTS: In response to treatment, both groups improved to a significant extent at follow-up, exceeding the FMUE minimum clinically important difference. Those in BUMP and CP saw a mean change of 5.68 (SE 0.76, p < 0.001) and 5.87 (SE 0.76, p < 0.001) respectively. There was no significant difference between treatment arms (mean difference of -0.20 (95% CI = [-2.37, 1.97], SE = 1.08, p = 0.86)). A response of ≥6 points was observed in 46% in BUMP and 50% in CP. INTERPRETATION: There was no beneficial effect of BUMP. The magnitude of change seen in both groups reflects the largest improvement achieved with just 22.5 h of TST in this population, matching or out-performing more invasive, time-intensive, and costly interventions proposed in recent years.","journal":"Annals of Clinical and Translational Neurology","year":2024,"id":472755,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":848059,"name":"Jacob M. Schauer","orcid":"0000-0002-9041-7082","position":1,"is_corresponding":false},{"id":737426,"name":"Shyam Prabhakaran","orcid":"0000-0003-3018-144X","position":2,"is_corresponding":false},{"id":947693,"name":"Alexandra Wax","orcid":null,"position":3,"is_corresponding":false},{"id":453401,"name":"Sebastian Urday","orcid":"0009-0008-2747-1503","position":4,"is_corresponding":false},{"id":383692,"name":"Sangeetha Madhavan","orcid":"0000-0001-6086-0027","position":5,"is_corresponding":false},{"id":289902,"name":"Daniel M. Corcos","orcid":"0000-0001-7440-6458","position":6,"is_corresponding":false},{"id":342044,"name":"Mary Ellen Stoykov","orcid":"0000-0002-9045-9231","position":7,"is_corresponding":false},{"id":672904,"name":"Erin King","orcid":"0000-0002-3724-3845","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:05:57.032095Z","pmid":"39688835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}