{"doi":"10.1002/acn3.52169","title":"No replicating evidence for anti‐amyloid‐β autoantibodies in cerebral amyloid angiopathy‐related inflammation","abstract":"OBJECTIVE: Elevated levels of anti-amyloid-β (anti-Aβ) autoantibodies in cerebrospinal fluid (CSF) have been proposed as a diagnostic biomarker for cerebral amyloid angiopathy-related inflammation (CAA-RI). We aimed to independently validate the immunoassay for quantifying these antibodies and evaluate its diagnostic value for CAA-RI. METHODS: We replicated the immunoassay to detect CSF anti-Aβ autoantibodies using CSF from CAA-RI patients and non-CAA controls with unrelated disorders and further characterized its performance. Moreover, we conducted a literature review of CAA-RI case reports to investigate neuropathological and CSF evidence of the nature of the inflammatory reaction in CAA-RI. RESULTS: = 0.51, p = 0.02). Assay levels were not elevated in CAA-RI patients (n = 6) compared to non-CAA controls (n = 20; p = 0.64). Literature review indicated only occasional presence of B-lymphocytes and plasma cells (i.e., antibody-producing cells), alongside the abundant presence of activated microglial cells, T-cells, and other monocyte lineage cells. CSF analysis did not convincingly indicate intrathecal IgG production. INTERPRETATION: We were unable to reproduce the reported elevation of anti-Aβ autoantibody concentration in CSF of CAA-RI patients. Our findings instead support nonspecific detection of IgG levels in CSF by the assay. Reviewed CAA-RI case reports suggested a widespread cerebral inflammatory reaction. In conclusion, our findings do not support anti-Aβ autoantibodies as a diagnostic biomarker for CAA-RI.","journal":"Annals of Clinical and Translational Neurology","year":2024,"id":447470,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1265535,"name":"Rian Roelofs","orcid":null,"position":1,"is_corresponding":false},{"id":466028,"name":"Lieke Jäkel","orcid":"0000-0002-9378-3256","position":2,"is_corresponding":false},{"id":251653,"name":"Steven M. Greenberg","orcid":"0000-0003-1792-8887","position":3,"is_corresponding":false},{"id":292620,"name":"Andreas Charidimou","orcid":"0000-0001-5891-337X","position":4,"is_corresponding":false},{"id":1079766,"name":"Ellis S. van Etten","orcid":"0000-0002-8301-6846","position":5,"is_corresponding":false},{"id":620298,"name":"Delphine Boche","orcid":"0000-0002-5884-130X","position":6,"is_corresponding":false},{"id":249221,"name":"Catharina J.M. Klijn","orcid":"0000-0002-8495-4578","position":7,"is_corresponding":false},{"id":466030,"name":"Floris H.B.M. Schreuder","orcid":"0000-0002-7815-0207","position":8,"is_corresponding":false},{"id":466029,"name":"H. Bea Kuiperij","orcid":"0000-0002-0635-7428","position":9,"is_corresponding":false},{"id":466031,"name":"Marcel M. Verbeek","orcid":"0000-0003-4635-7876","position":10,"is_corresponding":false},{"id":282543,"name":"E. van den Berg","orcid":"0000-0001-9004-934X","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:59.101070Z","pmid":"39268830","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}