{"doi":"10.1002/acn3.51851","title":"Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome","abstract":"Dravet syndrome (DS) is a monogenic, often refractory, epilepsy resultant from SCN1A haploinsufficiency in humans. A novel therapeutic target in DS that can be engaged in isolation or as adjunctive therapy is highly desirable. Here, we demonstrate reduced expression of the rodent glutamate transporter type 1 (GLT-1) in a DS mouse model, and in wild type mouse strains where Scn1a haploinsufficiency is most likely to cause epilepsy, indicating that GLT-1 depression may play a role in DS seizures. As GLT-1 can be upregulated by common and safe FDA-approved medications, this strategy may be an attractive, viable, and novel avenue for DS treatment.","journal":"Annals of Clinical and Translational Neurology","year":2023,"id":364217,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1119443,"name":"Benjamin Hui","orcid":null,"position":1,"is_corresponding":false},{"id":1119009,"name":"Rui Lin","orcid":"0000-0002-8416-2335","position":2,"is_corresponding":false},{"id":476505,"name":"Paul MacMullin","orcid":"0000-0002-1951-0217","position":3,"is_corresponding":false},{"id":920479,"name":"A. Pascual-Leone","orcid":"0000-0002-9429-1683","position":4,"is_corresponding":false},{"id":735153,"name":"Sheryl Anne D. Vermudez","orcid":"0000-0002-7020-8347","position":5,"is_corresponding":false},{"id":106056,"name":"Alexander Rotenberg","orcid":"0000-0002-6495-5928","position":6,"is_corresponding":false},{"id":447443,"name":"Mustafa Q. Hameed","orcid":"0000-0003-4004-5564","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:14:36.728255Z","pmid":"37452008","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}