{"doi":"10.1002/acn3.51815","title":"Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real‐time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.</jats:p>","journal":"Annals of Clinical and Translational Neurology","year":2023,"id":606490,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316356,"name":"Ganne Chaitanya","orcid":"0000-0002-1578-4210","position":1,"is_corresponding":false},{"id":1557007,"name":"Muhammad Ubaid Hafeez","orcid":null,"position":2,"is_corresponding":false},{"id":316357,"name":"Adeel Ilyas","orcid":"0000-0002-5545-4398","position":3,"is_corresponding":false},{"id":381495,"name":"Manojkumar Saranathan","orcid":"0000-0001-9020-9948","position":4,"is_corresponding":false},{"id":1557008,"name":"Jay Gavvala","orcid":null,"position":5,"is_corresponding":false},{"id":277125,"name":"Nitin Tandon","orcid":"0000-0002-2752-2365","position":6,"is_corresponding":false},{"id":1237749,"name":"Sandipan Pati","orcid":"0000-0003-4171-2138","position":7,"is_corresponding":false},{"id":1365739,"name":"Yash Shashank Vakilna","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real‐time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.</jats:p>","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37231611","pmcid":"PMC10351657","openalex_id":"https://openalex.org/W4378349465","authors":[],"funders":[],"total_grants":0,"fwci":6.6613,"citation_percentile":0.97664273,"influential_citations":0,"citation_trend":[{"year":2023,"count":2},{"year":2024,"count":13},{"year":2025,"count":22},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51815","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51815","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.51815","host_type":"publisher"},{"url":"https://doi.org/10.1002/acn3.51815","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37231611","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10351657","host_type":"repository"},{"url":"https://digitalcommons.library.tmc.edu/uthmed_docs/1532","host_type":"repository"},{"url":"https://doaj.org/article/9aa8817a1d8248d49647340b749f1709","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10351657/pdf/ACN3-10-1254.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10351657","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10351657?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neurological disorders and treatments","EEG and Brain-Computer Interfaces","Neuroscience and Neural Engineering","Humans","Pulvinar","Deep Brain Stimulation","Electrodes, Implanted","Epilepsy","Seizures"],"mesh_terms":["Electrodes, Implanted","Epilepsy","Humans","Seizures","Pulvinar","Deep Brain Stimulation"],"keywords":["Medicine","Deep brain stimulation","Neuromodulation","Epilepsy","Thalamus","Neuroscience","Parkinson's disease","Stimulation","Psychology","Pathology","Radiology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:39:39.299212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}