{"doi":"10.1002/acn3.51745","title":"Safety and patient experience with at‐home infusion of ocrelizumab for multiple sclerosis","abstract":"OBJECTIVE: This study aimed to evaluate safety (infusion-related reactions [IRRs]) and patient satisfaction (patient-reported outcomes [PROs]) for at-home ocrelizumab administration for patients with multiple sclerosis (MS). METHODS: This open-label study included adult patients with an MS diagnosis who had completed a ≥ 600-mg ocrelizumab dose, had a patient-determined disease steps score of 0 to 6 and had completed PROs. Eligible patients received a 600-mg ocrelizumab home-based infusion over 2 h, followed by 24-h and 2-week post-infusion follow-up calls. IRRs and adverse events (AEs) were documented during infusions and follow-up calls. PROs were completed before and 2 weeks post infusion. RESULTS: Overall, 99 of 100 expected patients were included (mean [SD] age, 42.3 [7.7] years; 72.7% female; 91.9% White). The mean (SD) infusion time was 2.5 (0.6) hours, and 75.8% of patients completed their ocrelizumab infusion between 2 to 2.5 h. The IRR incidence rate was 25.3% (95% CI: 16.7%, 33.8%)-similar to other shorter ocrelizumab infusion studies-and all AEs were mild/moderate. In total, 66.7% of patients experienced AEs, including itch, fatigue, and grogginess. Patients reported significantly increased satisfaction with the at-home infusion process and confidence in the care provided. Patients also reported a significant preference for at-home infusion compared with prior infusion center experiences. INTERPRETATION: IRRs and AEs occurred at acceptable rates during in-home infusions of ocrelizumab over a shorter infusion time. Patients reported increased confidence and comfort with the home infusion process. Findings from this study provide evidence of the safety and feasibility of home-based ocrelizumab infusion over a shorter infusion period.","journal":"Annals of Clinical and Translational Neurology","year":2023,"id":369445,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9425,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1128400,"name":"Haley Simpson","orcid":null,"position":1,"is_corresponding":false},{"id":433149,"name":"Eric Engebretson","orcid":null,"position":2,"is_corresponding":false},{"id":350081,"name":"Stefan Sillau","orcid":"0000-0002-8691-3139","position":3,"is_corresponding":false},{"id":433150,"name":"Brooke Valdez","orcid":null,"position":4,"is_corresponding":false},{"id":1128401,"name":"José Parra‐González","orcid":null,"position":5,"is_corresponding":false},{"id":913223,"name":"Ryan C. Winger","orcid":"0000-0001-9160-6646","position":6,"is_corresponding":false},{"id":1128402,"name":"Lou Anne Epperson","orcid":null,"position":7,"is_corresponding":false},{"id":1128064,"name":"Ashley Banks","orcid":"0000-0001-8407-5170","position":8,"is_corresponding":false},{"id":1128403,"name":"Kathryn Mitchell Pierce","orcid":null,"position":9,"is_corresponding":false},{"id":457730,"name":"Melanie Spotts","orcid":null,"position":10,"is_corresponding":false},{"id":352226,"name":"Katie O'Gean","orcid":null,"position":11,"is_corresponding":false},{"id":364686,"name":"Enrique Álvarez","orcid":"0000-0001-5854-9643","position":12,"is_corresponding":false},{"id":389007,"name":"Robert Gross","orcid":"0000-0001-6066-1159","position":13,"is_corresponding":false},{"id":854713,"name":"Amanda L. Piquet","orcid":"0000-0001-7349-6455","position":14,"is_corresponding":false},{"id":250722,"name":"Teri Schreiner","orcid":"0000-0002-3816-812X","position":15,"is_corresponding":false},{"id":983589,"name":"John R. Corboy","orcid":"0000-0003-4169-1461","position":16,"is_corresponding":false},{"id":913846,"name":"Jinglan Pei","orcid":null,"position":17,"is_corresponding":false},{"id":433151,"name":"Timothy L. Vollmer","orcid":null,"position":18,"is_corresponding":false},{"id":519378,"name":"Kavita Nair","orcid":"0000-0002-2442-2537","position":19,"is_corresponding":false},{"id":1013335,"name":"Britney Barrera","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:15:28.704894Z","pmid":"36811392","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}