{"doi":"10.1002/acn3.51463","title":"Lack of progression of beta dynamics after long‐term subthalamic neurostimulation","abstract":"OBJECTIVE: To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). METHODS: Participants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi-pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society-Unified Parkinson's Disease Rating Scale - motor subscale, MDS-UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state. RESULTS: After 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS-UPDRS III score. INTERPRETATION: These findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease.","journal":"Annals of Clinical and Translational Neurology","year":2021,"id":166955,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":492455,"name":"Kevin B. Wilkins","orcid":"0000-0001-5907-4029","position":1,"is_corresponding":false},{"id":362307,"name":"Jordan E. Parker","orcid":"0000-0001-9748-7617","position":2,"is_corresponding":false},{"id":392541,"name":"Matthew N. Petrucci","orcid":"0000-0003-3353-2532","position":3,"is_corresponding":false},{"id":693569,"name":"Yasmine M. Kehnemouyi","orcid":"0000-0002-0330-5198","position":4,"is_corresponding":false},{"id":362310,"name":"Raumin S. Neuville","orcid":"0000-0002-5182-7855","position":5,"is_corresponding":false},{"id":694340,"name":"Declan Cassini","orcid":null,"position":6,"is_corresponding":false},{"id":409100,"name":"Megan H. Trager","orcid":"0000-0002-7330-1627","position":7,"is_corresponding":false},{"id":492456,"name":"Mandy Miller Koop","orcid":"0000-0003-3047-8091","position":8,"is_corresponding":false},{"id":569951,"name":"Anca Velisar","orcid":"0000-0002-8349-7782","position":9,"is_corresponding":false},{"id":567158,"name":"Zack Blumenfeld","orcid":"0000-0002-4627-5582","position":10,"is_corresponding":false},{"id":694341,"name":"Emma J. Quinn","orcid":null,"position":11,"is_corresponding":false},{"id":487890,"name":"Jaimie M. Henderson","orcid":"0000-0002-3276-2267","position":12,"is_corresponding":false},{"id":362311,"name":"Helen Brontë‐Stewart","orcid":"0000-0002-1839-4541","position":13,"is_corresponding":false},{"id":693568,"name":"R Anderson","orcid":"0000-0001-7624-3138","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:45:54.042727Z","pmid":"34636182","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}