{"doi":"10.1002/acn3.51442","title":"Wearable myoelectric interface enables high‐dose, home‐based training in severely impaired chronic stroke survivors","abstract":"BACKGROUND: High-intensity occupational therapy can improve arm function after stroke, but many people lack access to such therapy. Home-based therapies could address this need, but they don't typically address abnormal muscle co-activation, an important aspect of arm impairment. An earlier study using lab-based, myoelectric computer interface game training enabled chronic stroke survivors to reduce abnormal co-activation and improve arm function. Here, we assess feasibility of doing this training at home using a novel, wearable, myoelectric interface for neurorehabilitation training (MINT) paradigm. OBJECTIVE: Assess tolerability and feasibility of home-based, high-dose MINT therapy in severely impaired chronic stroke survivors. METHODS: Twenty-three participants were instructed to train with the MINT and game for 90 min/day, 36 days over 6 weeks. We assessed feasibility using amount of time trained and game performance. We assessed tolerability (enjoyment and effort) using a customized version of the Intrinsic Motivation Inventory at the conclusion of training. RESULTS: Participants displayed high adherence to near-daily therapy at home (mean of 82 min/day of training; 96% trained at least 60 min/day) and enjoyed the therapy. Training performance improved and co-activation decreased with training. Although a substantial number of participants stopped training, most dropouts were due to reasons unrelated to the training paradigm itself. INTERPRETATION: Home-based therapy with MINT is feasible and tolerable in severely impaired stroke survivors. This affordable, enjoyable, and mobile health paradigm has potential to improve recovery from stroke in a variety of settings. Clinicaltrials.gov: NCT03401762.","journal":"Annals of Clinical and Translational Neurology","year":2021,"id":160353,"datarank":0.8653810615315602,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.32374337463492653,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.32374337463492653,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":21,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03401762"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672899,"name":"Vivek Paul","orcid":"0000-0002-7232-3875","position":1,"is_corresponding":false},{"id":672900,"name":"Prashanth Prakash","orcid":"0000-0001-5881-9738","position":2,"is_corresponding":false},{"id":673398,"name":"Torin Kovach","orcid":null,"position":3,"is_corresponding":false},{"id":673399,"name":"Gene Tacy","orcid":null,"position":4,"is_corresponding":false},{"id":673400,"name":"Goran Tomic","orcid":null,"position":5,"is_corresponding":false},{"id":672901,"name":"Sangsoo Park","orcid":"0000-0002-9617-6312","position":6,"is_corresponding":false},{"id":672902,"name":"Tyler Jacobson","orcid":"0000-0002-9655-1186","position":7,"is_corresponding":false},{"id":673401,"name":"Alix Jampol","orcid":null,"position":8,"is_corresponding":false},{"id":672903,"name":"Pooja Patel","orcid":"0000-0001-9714-0429","position":9,"is_corresponding":false},{"id":673402,"name":"Anya Chappel","orcid":null,"position":10,"is_corresponding":false},{"id":672904,"name":"Erin King","orcid":"0000-0002-3724-3845","position":11,"is_corresponding":false},{"id":462977,"name":"Marc W. Slutzky","orcid":"0000-0003-2269-7729","position":12,"is_corresponding":false},{"id":672898,"name":"Na‐Teng Hung","orcid":"0000-0002-0614-2849","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:44:43.908634Z","pmid":"34415114","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}