{"doi":"10.1002/acn3.51196","title":"Discordant Alzheimer's neurodegenerative biomarkers and their clinical outcomes","abstract":"OBJECTIVE: F-fluorodeoxyglucose-positron emission tomography, and brain atrophy. We aimed to assess the clinical outcomes of having discordant Alzheimer's neurodegenerative biomarkers. METHODS: A total of 721 non-demented individuals from the Alzheimer's Disease Neuroimaging Initiative database were included and then further categorized into concordant-negative, discordant, and concordant-positive groups. Demographic distributions of the groups were compared. Longitudinal changes in clinical outcomes and risk of conversion were assessed using linear mixed-effects models and multivariate Cox proportional hazard models, respectively. RESULTS: Discordant group was intermediate to concordant-negative and concordant-positive groups in terms of APOE ε4 positivity, CSF amyloid-beta, and phosphorylated tau. Compared with concordant-negative group, discordant group deteriorated faster in cognitive scores (Mini-Mental State Examination, the Clinical Dementia Rating Scale-Sum of Boxes, and the Functional Activities Questionnaire) and demonstrated greater rates of atrophy in brain structures (hippocampus, entorhinal cortex, and whole brain), and concordant-positive group performed worse over time than discordant group. Moreover, the risk of cognitive decline increased from concordant-negative to discordant to concordant-positive. The results from longitudinal analyses were validated in A+T+, cognitively normal, and mild cognitive impairment individuals, and were also validated by applying different cutoffs and neurodegenerative biomarkers. INTERPRETATION: Discordant neurodegenerative status denotes a stage of cognitive function which is intermediate between concordant-negative and concordant-positive. Identification of discordant cases would provide insights into intervention and new therapy approaches, particularly in A+T+ individuals. Moreover, this work may be a complement to the ATN scheme.","journal":"Annals of Clinical and Translational Neurology","year":2020,"id":110616,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7836,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":498266,"name":"Hong‐Qi Li","orcid":null,"position":1,"is_corresponding":false},{"id":525840,"name":"Lin Tan","orcid":"0000-0002-4921-1293","position":2,"is_corresponding":false},{"id":526546,"name":"Shi‐Dong Chen","orcid":null,"position":3,"is_corresponding":false},{"id":525841,"name":"Yu‐Xiang Yang","orcid":"0009-0003-3614-2713","position":4,"is_corresponding":false},{"id":293501,"name":"Ya‐Hui Ma","orcid":null,"position":5,"is_corresponding":false},{"id":284701,"name":"Chuantao Zuo","orcid":"0000-0002-8856-7217","position":6,"is_corresponding":false},{"id":291632,"name":"Qiang Dong","orcid":"0000-0002-3874-0130","position":7,"is_corresponding":false},{"id":291633,"name":"Lan Tan","orcid":"0000-0002-8759-7588","position":8,"is_corresponding":false},{"id":284702,"name":"Jin‐Tai Yu","orcid":"0000-0002-7686-0547","position":9,"is_corresponding":false},{"id":19445,"name":"Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":10,"is_corresponding":false},{"id":433493,"name":"Yu Guo","orcid":"0000-0002-1752-1254","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:12:57.988348Z","pmid":"32949193","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}