{"doi":"10.1002/acn3.338","title":"Alpha‐synuclein <scp>RT</scp>‐Qu<scp>IC</scp> in the <scp>CSF</scp> of patients with alpha‐synucleinopathies","abstract":"<jats:title>Abstract</jats:title><jats:p>We have developed a novel real‐time quaking‐induced conversion <jats:styled-content style=\"fixed-case\">RT</jats:styled-content>‐Qu<jats:styled-content style=\"fixed-case\">IC</jats:styled-content>‐based assay to detect alpha‐synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha‐synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that <jats:styled-content style=\"fixed-case\">RT</jats:styled-content>‐QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha‐synucleinopathies.</jats:p>","journal":"Annals of Clinical and Translational Neurology","year":2016,"id":642672,"datarank":12.268108945704164,"base_score":6.436150368369428,"endowment":6.436150368369428,"self_citation_contribution":0.9654225552554143,"citation_network_contribution":11.302686390448748,"self_endowment_contribution":0.9654225552554143,"citer_contribution":11.302686390448748,"corpus_percentile":null,"corpus_rank":null,"citation_count":623,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1671802,"name":"Lynne I. 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