{"doi":"10.1002/acm2.70012","title":"Enhanced dose prediction for head and neck cancer artificial intelligence‐driven radiotherapy based on transfer learning with limited training data","abstract":"Abstract Purpose Training deep learning dose prediction models for the latest cutting‐edge radiotherapy techniques, such as AI‐based nodal radiotherapy (AINRT) and Daily Adaptive AI‐based nodal radiotherapy (DA‐AINRT), is challenging due to limited data. This study aims to investigate the impact of transfer learning on the predictive performance of an existing clinical dose prediction model and its potential to enhance emerging radiotherapy approaches for head and neck cancer patients. Method We evaluated the impact and benefits of transfer learning by fine‐tuning a Hierarchically Densely Connected U‐net on both AINRT and DA‐AINRT patient datasets, creating Model AINRT (Study 1) and Model DA‐AINRT (Study 2). These models were compared against pretrained and baseline models trained from scratch. In Study 3, both fine‐tuned models were tested using DA‐AINRT patients' final adaptive sessions to assess Model AINRT ’s effectiveness on DA‐AINRT patients, given that the primary difference is planning target volume (PTV) sizes between AINRT and DA‐AINRT. Result Studies 1 and 2 revealed that the transfer learning model accurately predicted the mean dose within 0.71% and 0.86% of the prescription dose on the test data. This outperformed the pretrained and baseline models, which showed PTV mean dose prediction errors of 2.29% and 1.1% in Study 1, and 2.38% and 2.86% in Study 2 ( P < 0.05). Additionally, Study 3 demonstrated significant improvements in PTV dose prediction error with Model DA‐AINRT , with a mean dose difference of 0.86% ± 0.73% versus 2.26% ± 1.65% ( P < 0.05). This emphasizes the importance of training models for specific patient cohorts to achieve optimal outcomes. Conclusion Applying transfer learning to dose prediction models significantly improves prediction accuracy for PTV while maintaining similar dose performance in predicting organ‐at‐risk (OAR) dose compared to pretrained and baseline models. This approach enhances dose prediction models for novel radiotherapy methods with limited training data.","journal":"Journal of Applied Clinical Medical Physics","year":2025,"id":563023,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1066850,"name":"Austen Maniscalco","orcid":"0000-0001-7156-3239","position":1,"is_corresponding":false},{"id":473868,"name":"David J. Sher","orcid":"0000-0003-3943-7480","position":2,"is_corresponding":false},{"id":283110,"name":"Mu‐Han Lin","orcid":"0000-0002-7992-5465","position":3,"is_corresponding":false},{"id":280746,"name":"Steve Jiang","orcid":"0000-0002-3083-6752","position":4,"is_corresponding":false},{"id":280741,"name":"Dan Nguyen","orcid":"0000-0002-9590-0655","position":5,"is_corresponding":false},{"id":1308095,"name":"Hui‐Ju Wang","orcid":"0000-0002-3816-8664","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:56:09.638214Z","pmid":"40087841","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}