{"doi":"10.1002/9781119819950.ch27","title":"Strategies for Targeting the <scp>JAK</scp> ‐ <scp>STAT</scp> Pathway in Lymphoid Malignancies","abstract":"Cytokine-mediated JAK-STAT signaling is the key driver of growth, differentiation, apoptosis, and immune responses across multiple cell types, especially lymphocytes. A hallmark of malignant cells is their ability to subvert and highjack existing cellular components to create new and dysregulated signaling pathways not observed in normal counterparts. Thus, it is unsurprising that lymphoid malignancies exhibit profound dysregulation of JAK-STAT signaling through gain of positive signals as well as loss of negative signals. This review will focus on intracellular responses to cytokine signaling, mechanisms of dysregulation in lymphoid malignancies, therapeutic strategies to inhibit JAK-STAT signaling, progress toward translating these therapeutics to the clinic, and next steps needed to maximally target this key pathway.","journal":null,"year":2023,"id":399267,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":857822,"name":"Johnson Ung","orcid":"0000-0002-3275-0530","position":1,"is_corresponding":false},{"id":857825,"name":"Omar Elghawy","orcid":"0000-0002-0786-8035","position":2,"is_corresponding":false},{"id":907254,"name":"Peibin Yue","orcid":"0000-0001-6328-8441","position":3,"is_corresponding":false},{"id":535258,"name":"James Turkson","orcid":"0000-0002-6964-1602","position":4,"is_corresponding":false},{"id":1175490,"name":"and Thomas P. Loughran","orcid":null,"position":5,"is_corresponding":false},{"id":366762,"name":"Thomas P. Loughran","orcid":"0000-0003-4981-1691","position":0,"is_corresponding":true}],"reference_count":138,"raw_metadata":null,"created_at":"2026-07-19T01:19:51.724387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}