{"doi":"10.1002/9781119790419.ch9","title":"<b>OXIDATIVE STRESS AND REDOX SIGNALING IN CARCINOGENESIS</b>","abstract":"Carcinogenesis leads to a self-replicating transformed cell which conveys the generation of a larger number of cells with an increasing accumulation of abnormalities. Oxidative stress and reactive species (RS) participate at all stages of the malignancy/carcinogenic process aroused from both inherited and environmental factors. Cancer cells often exhibit increased generation of RS compared with normal cells, which is thought to provide favorable conditions for cancer cell growth, genetic instability, and survival. In physiological settings, reactive oxygen species/reactive nitrogen species exhibit substrate specificity. DNA damage caused by RS is a central element in the transformation process toward malignancy. However, it is evident that RS can promote/predispose to cancer development by oxidatively induced damage and modifications to lipids, and proteins/enzymes as well. RS, oxidative stress, and redox-dependent signaling cascades participate at all stages of the malignancy/carcinogenic process aroused from both inherited and environmental factors.","journal":null,"year":2025,"id":561906,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1464088,"name":"Aracely García‐García","orcid":"0000-0002-1699-9678","position":1,"is_corresponding":false},{"id":1464384,"name":"Thomas B. Kryston","orcid":null,"position":2,"is_corresponding":false},{"id":211407,"name":"Alexandros Georgakilas","orcid":"0000-0002-5971-0010","position":3,"is_corresponding":false},{"id":242330,"name":"Mihalis I. Panayiotidis","orcid":"0000-0002-1450-3552","position":4,"is_corresponding":false},{"id":242329,"name":"Aglaia Pappa","orcid":"0000-0003-0913-4315","position":5,"is_corresponding":false},{"id":242331,"name":"Rodrigo Franco","orcid":"0000-0003-3241-8615","position":0,"is_corresponding":true}],"reference_count":147,"raw_metadata":null,"created_at":"2026-07-19T02:56:01.883848Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}