{"doi":"10.1002/9781119739883.ch12","title":"ABCG2, THE BREAST CANCER RESISTANCE PROTEIN (BCRP)","abstract":null,"journal":"Drug Transporters","year":2022,"id":661205,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334607,"name":"Sabrina Lusvarghi","orcid":"0000-0003-1793-0450","position":1,"is_corresponding":false},{"id":259971,"name":"Cindy H. Chau","orcid":"0000-0002-6928-3833","position":2,"is_corresponding":false},{"id":1716362,"name":"Agnes Basseville","orcid":null,"position":3,"is_corresponding":false},{"id":109200,"name":"William D. Figg","orcid":"0000-0003-2428-5613","position":4,"is_corresponding":false},{"id":334608,"name":"Suresh V. Ambudkar","orcid":"0000-0002-2639-4955","position":5,"is_corresponding":false},{"id":3641,"name":"Susan E. Bates","orcid":"0000-0001-6708-0330","position":6,"is_corresponding":false},{"id":378982,"name":"Robert W. Robey","orcid":"0000-0002-0857-3650","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ABCG2, THE BREAST CANCER RESISTANCE PROTEIN (BCRP)","abstract":"The ABCG2 half-transporter plays an important in normal physiology predominantly in protective roles at the maternal-fetal barrier and the blood–brain barrier and affects oral bioavailability of substrates. High expression in some cancers suggests it may also play a role in multidrug resistance in cancer. Polymorphic variants have been shown to impair trafficking of the protein to the cell surface, with the Q141K variant being associated with a higher incidence of gout. Loss of ABCG2 expression forms the genetic bases of the Jr(a−) blood type. This chapter will focus on more recent ABCG2 studies with particular focus on genetic variants and atomic structures. These more recent findings may lead to a better understanding of the function of ABCG2, potentially leading to the development of better inhibitors or to the development of compounds that are not substrates for the transporter.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W4225773383","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119739883.ch12","host_type":"publisher"},{"url":"https://doi.org/10.1002/9781119739883.ch12","host_type":""}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Trace Elements in Health","MicroRNA in disease regulation"],"mesh_terms":[],"keywords":["Abcg2","Transporter","Biology","Multiple drug resistance","Cancer","Breast cancer","ATP-binding cassette transporter","Bioinformatics","Medicine","Cancer research","Drug resistance","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:35:21.827481Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}