{"doi":"10.1002/9781119665885.ch47","title":"Observational and Interventional Trials in Transfusion Medicine","abstract":null,"journal":"Practical Transfusion Medicine","year":2022,"id":677275,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1769615,"name":"Dean Fergusson","orcid":null,"position":1,"is_corresponding":false},{"id":1221755,"name":"Paul C. Hébert","orcid":"0000-0002-0440-8586","position":2,"is_corresponding":false},{"id":1769614,"name":"Alan T. Tinmouth","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Observational and Interventional Trials in Transfusion Medicine","abstract":"Randomised controlled clinical trials (RCTs) are the ‘gold standard’ clinical research design used to distinguish the risks and benefits of therapeutic interventions. In this chapter, the authors outline some of the methodological issues central to the development and conduct of observational and interventional trials, including RCTs, in transfusion medicine. To ascertain the effectiveness of an intervention, the RCT remains the preferred study design, as it should minimise the most important biases if properly conceived and executed. Two types of observational designs are often considered in clinical research: case–control studies and cohort or prognostic studies. For therapeutic interventions, the highest quality of evidence is provided by a well-performed RCT. As more research groups form to address unanswered therapeutic questions in transfusion medicine, investigators will invariably better understand the strengths and limitations of different RCT and observational study design characteristics.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4281645587","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119665885.ch47","host_type":"publisher"},{"url":"https://doi.org/10.1002/9781119665885.ch47","host_type":""}],"fields_of_study":["Blood transfusion and management","Blood donation and transfusion practices","Trauma, Hemostasis, Coagulopathy, Resuscitation"],"mesh_terms":[],"keywords":["Observational study","Randomized controlled trial","Medicine","Psychological intervention","Clinical study design","Research design","Gold standard (test)","Clinical trial","Transfusion medicine","Intervention (counseling)","Intensive care medicine","Medical physics","Surgery","Blood transfusion","Pathology","Internal medicine","Psychiatry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T03:55:02.403569Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}