{"doi":"10.1002/9781119660699.ch21","title":"<scp>OATP</scp> Transporters in Hepatic and Intestinal Uptake of Orally Administered Drugs","abstract":"Organic anion transporting polypeptide (OATP) transporters expressed in the liver and intestine mediate the uptake of many clinically important drugs. Impaired transport function of hepatic and intestinal OATPs due to genetic variation, drug–drug interactions (DDIs) or drug–food interactions may lead to altered drug disposition and toxicities. Extensive efforts have been made to assess OATP-mediated DDIs in order to mitigate unwanted adverse drug effects. Increasing literature reports suggest that function of OATPs can be modulated at various levels, including genetic variation, transcriptional, and post-translational levels. The current review provides an up-to-date summary on the role of hepatic and intestine OATPs in altered drug disposition of orally administered drugs.","journal":null,"year":2023,"id":415539,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417163,"name":"Taleah Farasyn","orcid":null,"position":1,"is_corresponding":false},{"id":417164,"name":"Alexandra Crowe","orcid":null,"position":2,"is_corresponding":false},{"id":416397,"name":"Khondoker Alam","orcid":"0000-0001-8757-2412","position":3,"is_corresponding":false},{"id":1025199,"name":"Lucila Garcia‐Contreras","orcid":"0000-0001-6605-953X","position":4,"is_corresponding":false},{"id":369157,"name":"Yifan Tu","orcid":"0000-0002-2728-6753","position":5,"is_corresponding":false},{"id":369160,"name":"Lu Wang","orcid":"0000-0002-8643-6790","position":6,"is_corresponding":false},{"id":416401,"name":"Wei Yue","orcid":"0000-0002-7444-2026","position":0,"is_corresponding":true}],"reference_count":119,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:22:12.933438Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}