{"doi":"10.1002/9781119329725.ch37","title":"Metformin and Lactic Acidosis","abstract":null,"journal":"Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants","year":2018,"id":659492,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":726971,"name":"Jean‐Daniel Lalau","orcid":"0000-0001-7167-9872","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Metformin and Lactic Acidosis","abstract":"Metformin's variable contribution to lactic acidosis is reflected by use of the ambiguous term “metformin-associated lactic acidosis” (MALA). While metformin is acknowledged as having a primary role in the treatment of type 2 diabetes mellitus, many cases of lactic acidosis have been reported in metformin- treated diabetic patients. It is therefore essential to distinguish between “generic” MALA on one hand and a condition due exclusively to metformin on the other. In clinical practice, typical settings for metformin-induced lactic acidosis (MILA) include metformin intoxication and acute metformin accumulation. The causal role of metformin as the triggering agent in lactic acidosis is difficult to assess because metformin accumulation does not necessarily lead to hyperlactatemia, and hyperlactatemia does not necessarily lead to acidosis. Although massive metformin accumulation may alter mitochondrial respiration, hyperlactatemia is highly unlikely to result from intestinal lactate production as long as the liver is able to eliminate the excess lactate.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W2793417881","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9781119329725.ch37","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119329725.ch37","host_type":"publisher"},{"url":"https://doi.org/10.1002/9781119329725.ch37","host_type":""}],"fields_of_study":["Metabolism, Diabetes, and Cancer","Diabetes and associated disorders","Neurological and metabolic disorders"],"mesh_terms":[],"keywords":["Hyperlactatemia","Metformin","Lactic acidosis","Medicine","Acidosis","Diabetes mellitus","Type 2 diabetes","Internal medicine","Endocrinology","Pharmacology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T07:01:45.826975Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}