{"doi":"10.1002/9781119220787.ch41","title":"COARTEM (Artemether/Lumefantrine)","abstract":null,"journal":"Antibiotics Manual","year":2017,"id":654239,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"COARTEM (Artemether/Lumefantrine)","abstract":"This chapter provides the basic characteristics, side effects/toxicity, drug interactions, and dosing of the coartem (artemether/lumefantrine). Artemether is metabolized into dihydroartemisinin (DHA). Lumefantrine inhibits the formation of β-hematin by forming a complex with hemin. Both artemether and lumefantrine inhibit nucleic acid and protein synthesis. Artemether/lumefantrine tablets should be taken with food. When artemether/lumefantrine is coadministered with an inhibitor of CYP3A4, including grapefruit juice, it may result in increased concentrations of artemether and/or lumefantrine and potentiate QT prolongation. When artemether/lumefantrine is coadministered with inducers of CYP3A4 it may result in decreased concentrations of artemether and/or lumefantrine and loss of antimalarial efficacy. Coartem tablets contain 20 mg of artemether and 120 mg of lumefantrine. Artemether/lumefantrine is not approved for patients with severe or complicated Plasmodium falciparum malaria. It is not approved for the prevention of malaria. Coartem tablets may be crushed and mixed with a small amount of water.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W2753392820","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2022,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9781119220787.ch41","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119220787.ch41","host_type":"publisher"},{"url":"https://doi.org/10.1002/9781119220787.ch41","host_type":""}],"fields_of_study":["Malaria Research and Control"],"mesh_terms":[],"keywords":["Artemether/lumefantrine","Artemether","Lumefantrine","Dihydroartemisinin","Pharmacology","Medicine","Malaria","Dosing","Artemisinin","Plasmodium falciparum","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T05:07:46.796906Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}