{"doi":"10.1002/9780470015902.a0005164.pub3","title":"Receptors and Human Nervous System Disorders","abstract":"<jats:title>Abstract</jats:title>\n          <jats:sec>\n            <jats:label/>\n            <jats:p>Neurons, building blocks of the mammalian nervous system, mainly communicate with each other through synapses in which signal transmission is mediated by neurotransmitters released from the presynaptic neuron and sensed by the postsynaptic neuron. These endogenous chemicals released from the nerve terminal diffuse through the very narrow extracellular space between the neurons and bind to specific membrane proteins called receptors, thereby mediating signal propagation. Receptors are divided into two large families comprising those causing the activation of second messengers and those including an ionic pore which opens upon neurotransmitter binding and which controls flow of ions across the cell membrane. Also called ligand‐gated ion channels (LGIC), they mediate fast neurotransmission essential for the complex signal processing in the central nervous system. Reliable transmission of signals between neurons is highly dependent on accurate functioning of LGICs. Genetically transmissible nervous system disorders can be caused by mutations in genes coding for LGICs, resulting in dramatically altered neurotransmission.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Key Concepts</jats:title>\n            <jats:p>\n              <jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>In this work we review the determinant role of ligand gated ion channels in brain function and the alterations related to genetic variants.</jats:p>\n                </jats:list-item>\n              </jats:list>\n            </jats:p>\n          </jats:sec>","journal":"Encyclopedia of Life Sciences","year":2017,"id":41598,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200175,"name":"Daniel Bertrand","orcid":null,"position":1,"is_corresponding":false},{"id":200174,"name":"Frédéric Knoflach","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W2578918419","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9780470015902.a0005164.pub3","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/9780470015902.a0005164.pub3","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/9780470015902.a0005164.pub3","host_type":"publisher"},{"url":"https://doi.org/10.1002/9780470015902.a0005164.pub3","host_type":"journal"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Nicotinic Acetylcholine Receptors Study","Genetics and Neurodevelopmental Disorders","Biology","Medicine"],"mesh_terms":[],"keywords":["Neurotransmission","Nervous system","Neuroscience","Postsynaptic potential","Neurotransmitter receptor","Biology","Neurotransmitter","Neuron","Neurotransmitter Agents","Ion channel","Ion channel linked receptors","Synaptic cleft","Receptor","Cell biology","Central nervous system","Glutamate receptor","Biochemistry","AMPA receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-13T02:52:30.362730Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}