{"doi":"10.1002/2211-5463.13919","title":"Alcohol induces α2‐6sialo mucin <scp>O</scp> ‐glycans that kill <scp>U</scp> 937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 ( <scp>S</scp> iglec 7)","abstract":"Alcohol misuse increases infections and cancer fatalities, but mechanisms underlying its toxicity are ill-defined. We show that alcohol treatment of human tracheobronchial epithelial cells leads to inactivation of giantin-mediated Golgi targeting of glycosylation enzymes. Loss of core 2 N-acetylglucosaminyltransferase 1, which uses only giantin for Golgi targeting, coupled with shifted targeting of other glycosylation enzymes to Golgi matrix protein 130-Golgi reassembly stacking protein 65, the site normally used by core 1 enzyme, results in loss of sialyl Lewis x and increase of sialyl Lewis a and α2-6sialo mucin O-glycans. The α2-6sialo mucin O-glycans induced by alcohol cause death of U937 macrophages mediated by sialic acid-binding immunoglobulin-like lectin 7. These results provide a mechanistic insight into the cause of the toxic effects of alcohol and might contribute to the development of therapies to alleviate its toxicity.","journal":"FEBS Open Bio","year":2024,"id":478031,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1316914,"name":"Vishwanath‐Reddy Hothpet","orcid":null,"position":1,"is_corresponding":false},{"id":373088,"name":"Ganapati Bhat","orcid":null,"position":2,"is_corresponding":false},{"id":326353,"name":"Kristina L. Bailey","orcid":"0000-0003-2990-9042","position":3,"is_corresponding":false},{"id":1316559,"name":"Lei Li","orcid":"0000-0002-9151-188X","position":4,"is_corresponding":false},{"id":671004,"name":"Derrick R. Samuelson","orcid":"0000-0002-5356-1413","position":5,"is_corresponding":false},{"id":1316558,"name":"Pi‐Wan Cheng","orcid":"0000-0002-8624-2865","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39592427","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}