{"doi":"10.1002/2211-5463.13566","title":"The <scp>NLRP3</scp> inflammasome – interleukin 1β axis in uveal melanoma","abstract":"Uveal melanoma (UM) is the most common primary intraocular cancer in the adult population. Recent studies suggested that the NLRP3 inflammasome could be a therapeutic target for cutaneous melanoma (CM), but the role of NLRP3 in UM remains unknown. Here, we analyzed the NLRP3-IL-1β axis in 5 UM and 4 CM cell lines. Expression of NLRP3 mRNA in UM and CM was low, and expression in UM was lower than in CM (P < 0.001). NLRP3 protein levels were below detection limit for all cell lines. UM exhibited lower baseline IL-1β secretion than CM, especially when compared to the Hs294t cell line (P < 0.05). Bioinformatic analysis of human tumor samples showed that UM has significantly lower expression of NLRP3 and IL-1β compared with CM. In conclusion, our work shows evidence of extremely low NLRP3 expression and IL-1β secretion by melanoma cells and highlight differences between CM and UM.","journal":"FEBS Open Bio","year":2023,"id":384581,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":884527,"name":"Nikolaos E. Efstathiou","orcid":"0000-0002-6635-0391","position":1,"is_corresponding":false},{"id":908349,"name":"Dimitrios P. Ntentakis","orcid":"0000-0003-0524-4752","position":2,"is_corresponding":false},{"id":880977,"name":"Zhen Yu","orcid":"0000-0003-3456-3584","position":3,"is_corresponding":false},{"id":922849,"name":"Toshio Narimatsu","orcid":"0000-0003-2844-1046","position":4,"is_corresponding":false},{"id":1152085,"name":"Evangelos S. Gragoudas","orcid":"0000-0002-2437-5283","position":5,"is_corresponding":false},{"id":54593,"name":"Ivana K. Kim","orcid":"0000-0003-0310-6129","position":6,"is_corresponding":false},{"id":407549,"name":"Demetrios G. Vavvas","orcid":"0000-0002-8622-6478","position":7,"is_corresponding":false},{"id":922845,"name":"Victor Correa","orcid":"0000-0001-5723-7883","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T01:17:37.110513Z","pmid":"36707938","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}