{"doi":"10.1002/1873-3468.14555","title":"The ubiquitin‐like protein Hub1/<scp>UBL</scp>‐5 functions in <scp>pre‐mRNA</scp> splicing in <i>Caenorhabditis elegans</i>","abstract":"The ubiquitin-like protein Hub1/UBL-5 associates with proteins non-covalently. Hub1 promotes alternative splicing and splicing of precursor mRNAs with weak introns in yeast and mammalian cells; however, its splicing function has remained elusive in multicellular organisms. Here, we demonstrate the splicing function of Hub1/UBL-5 in the free-living nematode Caenorhabditis elegans. Hub1/UBL-5 binds to the HIND-containing splicing factors Snu66/SART-1 and PRP-38 and associates with other spliceosomal proteins. C. elegans hub1/ubl-5 mutants die at the Larval 3 stage and show splicing defects for selected targets, similar to the mutants in yeast and mammalian cells. UBL-5 complemented growth and splicing defects in Schizosaccharomyces pombe hub1 mutants, confirming its functional conservation. Thus, UBL-5 is important for C. elegans development and plays a conserved pre-mRNA splicing function.","journal":"FEBS Letters","year":2022,"id":266912,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":927066,"name":"Pallavi Sharma","orcid":"0000-0002-6274-1846","position":1,"is_corresponding":false},{"id":569159,"name":"Nagesh Y. Kadam","orcid":"0000-0001-5236-1615","position":2,"is_corresponding":false},{"id":927067,"name":"Navneet Shahi","orcid":"0000-0002-5060-8810","position":3,"is_corresponding":false},{"id":927417,"name":"Ane Nishitha","orcid":null,"position":4,"is_corresponding":false},{"id":569162,"name":"Kavita Babu","orcid":"0000-0002-7527-3666","position":5,"is_corresponding":false},{"id":927068,"name":"Shravan Kumar Mishra","orcid":"0000-0003-3899-0495","position":6,"is_corresponding":false},{"id":927065,"name":"Kiran Kumar Kolathur","orcid":"0000-0003-4173-0977","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:26:58.102271Z","pmid":"36480405","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}