{"doi":"10.1002/1873-3468.14303","title":"Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer’s disease","abstract":"L‐ergothioneine (ERGO) is a potent antioxidant with cytoprotective effects. To study ERGO biodistribution and detect oxidative stress in vivo , we report an efficient and reproducible preparation of [ 11 C]‐labeled ERGO PET radioligand based on protecting the histidine carboxylic group with a methyl ester. Overall, this new protection approach using methyl ester improved the chemical yield of a 4‐step reaction from 14% to 24% compared to the previous report using t ‐butyl ester. The [ 11 C]CH 3 methylation of the precursor provided the desired product with 55 ± 10% radiochemical purity and a molar activity of 450 ± 200 TBq·mmol −1 . The [ 11 C]ERGO radioligand was able to detect threshold levels of oxidative stress in a preclinical animal model of Alzheimer’s disease.","journal":"FEBS Letters","year":2022,"id":281089,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":747766,"name":"Clayton A. Whitmore","orcid":null,"position":1,"is_corresponding":false},{"id":776521,"name":"Justin R. Haynes","orcid":null,"position":2,"is_corresponding":false},{"id":775885,"name":"Adam J. Rosenberg","orcid":"0000-0003-2459-7043","position":3,"is_corresponding":false},{"id":479401,"name":"Mohammed Noor Tantawy","orcid":"0000-0001-5975-7540","position":4,"is_corresponding":false},{"id":698003,"name":"Todd E. Peterson","orcid":"0000-0002-5951-7384","position":5,"is_corresponding":false},{"id":753318,"name":"Fiona E. Harrison","orcid":"0000-0003-1121-0647","position":6,"is_corresponding":false},{"id":775886,"name":"Robert B. Beelman","orcid":"0000-0002-6795-2984","position":7,"is_corresponding":false},{"id":530674,"name":"Printha Wijesinghe","orcid":"0000-0002-6548-4689","position":8,"is_corresponding":false},{"id":747253,"name":"Joanne A. Matsubara","orcid":"0000-0002-6236-9191","position":9,"is_corresponding":false},{"id":747254,"name":"Wellington Pham","orcid":"0000-0002-8408-7611","position":10,"is_corresponding":false},{"id":776520,"name":"William J. Behof","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:29:07.472902Z","pmid":"35100442","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}