{"doi":"10.1002/1873-3468.14163","title":"Circulating integrin α<sub>4</sub>β<sub>7</sub><sup>+</sup> CD4 T cells are enriched for proliferative transcriptional programs in HIV infection","abstract":"HIV preferentially infects α 4 β 7 + CD4 T cells, forming latent reservoirs that contribute to HIV persistence during antiretroviral therapy. However, the properties of α 4 β 7 + CD4 T cells in blood and mucosal compartments remain understudied. Employing two distinct models of HIV infection, HIV‐infected humans and simian–human immunodeficiency virus (SHIV)‐infected rhesus macaques, we show that α 4 β 7 + CD4 T cells in blood are enriched for genes regulating cell cycle progression and cellular metabolism. Unlike their circulating counterparts, rectal α 4 β 7 + CD4 T cells exhibited a core tissue‐residency gene expression program. These features were conserved across primate species, indicating that the environment influences memory T‐cell transcriptional networks. Our findings provide an important molecular foundation for understanding the role of α 4 β 7 in HIV infection.","journal":"FEBS Letters","year":2021,"id":186088,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340725,"name":"Jamin W. Roh","orcid":null,"position":1,"is_corresponding":false},{"id":743357,"name":"Niharika N. Rane","orcid":"0000-0002-7062-5095","position":2,"is_corresponding":false},{"id":713356,"name":"Ashok Reddy Dinasarapu","orcid":"0000-0002-1423-1518","position":3,"is_corresponding":false},{"id":744083,"name":"Daphne D. Tran","orcid":null,"position":4,"is_corresponding":false},{"id":280890,"name":"Vijayakumar Velu","orcid":"0000-0003-4238-1924","position":5,"is_corresponding":false},{"id":301948,"name":"Anandi N. Sheth","orcid":"0000-0002-6305-2727","position":6,"is_corresponding":false},{"id":382869,"name":"Igho Ofotokun","orcid":"0000-0003-2735-1903","position":7,"is_corresponding":false},{"id":253824,"name":"Rama Rao Amara","orcid":"0000-0002-6309-6797","position":8,"is_corresponding":false},{"id":340072,"name":"Colleen F. Kelley","orcid":"0000-0001-5611-0119","position":9,"is_corresponding":false},{"id":744084,"name":"Elaine Waetjen","orcid":null,"position":10,"is_corresponding":false},{"id":297247,"name":"Smita S. Iyer","orcid":"0000-0002-8918-7005","position":11,"is_corresponding":false},{"id":558226,"name":"Yashavanth Shaan Lakshmanappa","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:48:42.632147Z","pmid":"34278574","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}