{"doi":"10.1002/0470090839.ch14","title":"The Molecular Workings of the\n            <i>Neurospora</i>\n            Biological Clock","abstract":null,"journal":"Novartis Foundation Symposia","year":2003,"id":607651,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1560375,"name":"Antonio Pregueiro","orcid":null,"position":1,"is_corresponding":false},{"id":830239,"name":"Kwangwon Lee","orcid":"0000-0001-8225-4220","position":2,"is_corresponding":false},{"id":1560379,"name":"Deanna Denault","orcid":null,"position":3,"is_corresponding":false},{"id":1560380,"name":"Hildur Colot","orcid":null,"position":4,"is_corresponding":false},{"id":939414,"name":"Minou Nowrousian","orcid":"0000-0003-0075-6695","position":5,"is_corresponding":false},{"id":1560381,"name":"Jennifer J. Loros","orcid":null,"position":6,"is_corresponding":false},{"id":1560382,"name":"Jay C. Dunlap","orcid":null,"position":7,"is_corresponding":false},{"id":1560373,"name":"Allan C. Froehlich","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Molecular Workings of the\n            <i>Neurospora</i>\n            Biological Clock","abstract":"In Neurosporacrassa the FRQ/WC feedback loop has been shown to be central to the function of the circadian clock. Similar to other eukaryotic systems it is based on a transcription-translation PAS heterodimer type feedback. FRQ levels cycle with a period identical to that of the Neurospora circadian cycle and its expression is rapidly induced by light. A complex of White Collar 1 (WC-1) and White Collar 2 (WC-2) (the WCC) is required for the transcriptional activation of frq. The oscillation in frq message is transcriptionally regulated via a single necessary and sufficient cis-acting element in the frq promoter, the Clock-Box (CB) bound by WCC. Light-induction of frq transcription is mediated by WCC binding to two cis-acting elements (LREs) in the frq promoter. WC-1, with flavin adenine dinucleotide (FAD) as a cofactor, is the blue-light photoreceptor. The original description of a frq-null strain, frq9, (Loros et al 1986) included a description of oscillations in asexual conidial banding that occasionally appeared following 3 to 7 days of arrhythmic development now referred to as FLO for FRQ-less oscillator. Unlike the intact clock, FLO period is sensitive to media composition. We have identified a circadianly regulated gene whose mutation interferes with FLO even under temperature entrainment conditions. This same mutation affects the circadian clock in a frq+ background causing a shorter period length as well as temperature response defects. This gene may be an entry point to study the connection between the biological clock and other basic cellular mechanisms.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14712922","pmcid":null,"openalex_id":"https://openalex.org/W1526801379","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R37GM34985","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH44651","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F0470090839.ch14","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/0470090839.ch14","host_type":"publisher"},{"url":"https://doi.org/10.1002/0470090839.ch14","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14712922","host_type":"repository"}],"fields_of_study":["Circadian rhythm and melatonin","Photoreceptor and optogenetics research"],"mesh_terms":["Circadian Rhythm","Fungal Proteins","Genes, Fungal","Light","Models, Biological","Neurospora crassa","Temperature","Photoreceptors, Microbial"],"keywords":["Neurospora","Biological clock","Molecular clock","Biology","Genetics","Gene","Neuroscience","Neurospora crassa","Phylogenetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:46:27.486351Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}