{"doi":"10.1001/jamanetworkopen.2025.31038","title":"Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults","abstract":"Importance: Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). Objective: To examine associations between plasma biomarkers of amyloid, tau, neuroaxonal damage, and glial activation with SCD in a heterogeneous cohort of Hispanic and/or Latino adults. Design, Setting, and Participants: This cross-sectional study used survey-weighted data from the Study of Latinos-Investigation of Neurocognitive Aging, an ancillary study of the Hispanic Community Health Study/Study of Latinos. Participants were aged 50 to 86 years and resided in 4 major US cities. Data were collected from 2016 to 2018 and analyzed between December 2024 and June 2025. Exposure: Plasma biomarkers included amyloid-beta (Aβ42/40), phosphorylated tau-181 (ptau-181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP), quantified using Simoa (Quanterix HD-X) and log-transformed (ln) to reduce skewness. Main Outcomes and Measures: SCD was assessed using the short-form Everyday Cognition Scale (ECog-12), evaluating global-, executive-, and memory-related SCD, and a single-item cognitive concerns question. Survey-weighted linear and logistic regression models tested associations between biomarkers and SCD, adjusting for demographic, cardiovascular, kidney, and APOE genotype covariates. Results: Among 5712 adults (mean [SD] age, 63.47 (8.15) years; unweighted 3663 [53.92%] female), higher ln(ptau-181) was associated with ECog-12 memory (unstandardized β = 0.088; 95% CI, 0.005-0.170). Higher ln(NfL) levels were associated with greater ECog-12 global (unstandardized β = 0.169; 95% CI, 0.074-0.265), executive (unstandardized β = 0.182; 95% CI, 0.087-0.277), and memory (unstandardized β = 0.156; 95% CI, 0.065-0.248) domains. Higher ln(GFAP) levels were associated with greater ECog-12 global (unstandardized β = 0.109; 95% CI, 0.019-0.198) and executive (unstandardized β = 0.121; 95% CI, 0.031-0.211) domains. Ln(Aβ42/40) was not associated with SCD domains. Cognitive concerns significantly modified the associations between ln(NfL) and ECog-12 domains, with more pronounced associations among those reporting cognitive concerns. No biomarkers were associated with the single-item cognitive concerns score. Conclusions and Relevance: In this study of middle-aged and older Hispanic and/or Latino adults, plasma biomarkers of p-tau181, NfL, and GFAP, but not Aβ42/40, were associated with greater SCD. These findings underscore their potential utility in early ADRD detection strategies.","journal":"JAMA Network Open","year":2025,"id":522004,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":303806,"name":"Wassim Tarraf","orcid":"0000-0001-8888-7918","position":1,"is_corresponding":false},{"id":673794,"name":"Kevin A. González","orcid":"0000-0002-8958-3884","position":2,"is_corresponding":false},{"id":1257814,"name":"Deisha F. Valencia","orcid":null,"position":3,"is_corresponding":false},{"id":303809,"name":"Ariana M. Stickel","orcid":"0000-0002-6312-2377","position":4,"is_corresponding":false},{"id":1390640,"name":"Natasha Z. Anita","orcid":"0009-0007-9179-1539","position":5,"is_corresponding":false},{"id":427001,"name":"Daniela Sotres‐Alvarez","orcid":"0000-0002-3226-6140","position":6,"is_corresponding":false},{"id":328215,"name":"Bonnie Levin","orcid":"0000-0003-0931-296X","position":7,"is_corresponding":false},{"id":374096,"name":"Michael A. Yassa","orcid":"0000-0002-8635-1498","position":8,"is_corresponding":false},{"id":455423,"name":"Haibo Zhou","orcid":"0000-0002-2468-0093","position":9,"is_corresponding":false},{"id":37779,"name":"Martha L. Daviglus","orcid":"0000-0002-6791-8727","position":10,"is_corresponding":false},{"id":546833,"name":"Amber Pirzada","orcid":"0000-0003-0526-3611","position":11,"is_corresponding":false},{"id":680003,"name":"Zachary T. Goodman","orcid":"0000-0002-0126-4425","position":12,"is_corresponding":false},{"id":303810,"name":"Bharat Thyagarajan","orcid":"0000-0001-6968-6985","position":13,"is_corresponding":false},{"id":421766,"name":"Linda C. Gallo","orcid":"0000-0002-3678-5888","position":14,"is_corresponding":false},{"id":303812,"name":"Hector M. González","orcid":"0000-0003-4867-7902","position":15,"is_corresponding":false},{"id":474540,"name":"Freddie Márquez","orcid":"0000-0001-9916-9225","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:49:49.198144Z","pmid":"40911305","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}