{"doi":"10.1001/jamanetworkopen.2022.50219","title":"Evaluation of the Association Between Congenital Cytomegalovirus Infection and Pediatric Acute Lymphoblastic Leukemia","abstract":"Importance: Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer, and a leading cause of death in children. Understanding the causes of pediatric ALL is necessary to enable early detection and prevention; congenital cytomegalovirus (cCMV) has recently been identified as a potential moderate-to-strong factor associated with risk for ALL. Objective: To compare the prevalence of cCMV infection between ALL cases and matched controls. Design, Setting, and Participants: In this population-based case-control study of ALL cases and matched controls, cases consisted of children aged 0 to 14 years between 1987 and 2014 with an ALL diagnosis identified through the Michigan Cancer Surveillance Program and born in Michigan on or after October 1, 1987. Cancer-free controls were identified by the Michigan BioTrust for Health and matched on age, sex, and mother's race and ethnicity. Data were analyzed from November to May 2022. Exposures: cCMV infection measured by quantitative polymerase chain reaction in newborn dried blood spots. Main Outcomes and Measures: ALL diagnosed in children aged 0 to 14 years. Results: A total of 1189 ALL cases and 4756 matched controls were included in the study. Bloodspots were collected from participants at birth, and 3425 (57.6%) participants were male. cCMV was detected in 6 ALL cases (0.5%) and 21 controls (0.4%). There was no difference in the odds of cCMV infection comparing ALL cases with controls (odds ratio, 1.30; 95% CI, 0.52-3.24). Immunophenotype was available for 536 cases (45.1%) and cytogenetic data for 127 (27%). When stratified by subtype characteristics, hyperdiploid ALL (74 cases) was associated with 6.26 times greater odds of cCMV infection compared with unmatched controls (95% CI, 1.44-27.19). Conclusions and Relevance: In this case-control study of cCMV and pediatric ALL, cCMV was associated with increased risk of hyperdiploid ALL. These findings encourage continued research.","journal":"JAMA Network Open","year":2023,"id":343792,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9692,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":326174,"name":"Mark R. Schleiss","orcid":"0000-0002-2108-9433","position":1,"is_corresponding":false},{"id":1082258,"name":"Anthony J. Hooten","orcid":null,"position":2,"is_corresponding":false},{"id":1081818,"name":"Erica Langer","orcid":"0000-0002-4528-5922","position":3,"is_corresponding":false},{"id":910480,"name":"Nelmary Hernandez-Alvarado","orcid":"0000-0001-5928-8983","position":4,"is_corresponding":false},{"id":519606,"name":"Michelle A. Roesler","orcid":"0000-0002-0844-8796","position":5,"is_corresponding":false},{"id":921485,"name":"Jeannette M. Sample","orcid":"0000-0002-9658-0382","position":6,"is_corresponding":false},{"id":407521,"name":"Lindsay A. Williams","orcid":"0000-0003-3842-4629","position":7,"is_corresponding":false},{"id":800705,"name":"David S. Dickens","orcid":"0000-0001-8821-6022","position":8,"is_corresponding":false},{"id":302165,"name":"Rajen Mody","orcid":"0000-0001-5574-1779","position":9,"is_corresponding":false},{"id":889191,"name":"Yaddanapudi Ravindranath","orcid":"0000-0001-9577-9624","position":10,"is_corresponding":false},{"id":1082259,"name":"Kate Gowans","orcid":null,"position":11,"is_corresponding":false},{"id":1082260,"name":"Matthew G. Pridgeon","orcid":null,"position":12,"is_corresponding":false},{"id":363576,"name":"Logan G. Spector","orcid":"0000-0003-2516-0222","position":13,"is_corresponding":false},{"id":48173,"name":"HEATHER H. NELSON","orcid":"0000-0003-1901-9513","position":14,"is_corresponding":false},{"id":899797,"name":"Jennifer M. Geris","orcid":"0000-0001-8710-3691","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T01:11:26.556051Z","pmid":"36622672","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}