{"doi":"10.1001/jamanetworkopen.2022.49993","title":"Outcomes of Patients With Atrial Fibrillation Following Thrombectomy for Stroke","abstract":"Importance: Patients with atrial fibrillation (AF) treated with mechanical thrombectomy (MT) for acute ischemic stroke (AIS) have been reported to experience worse outcomes compared with patients without AF. Objective: To assess differences between patients with AF and their counterparts without AF treated with MT for AIS, focusing on safety outcomes, clinical outcomes, and baseline characteristics in both groups. Data Sources: A systematic literature review of the English language literature from inception to July 14, 2022, was conducted using Web of Science, Embase, Scopus, and PubMed databases. Study Selection: Studies that focused on patients with and without AF treated with MT for AIS were included. Multiple reviewers screened studies to identify studies included in analysis. Data Extraction and Synthesis: Data were extracted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline to ensure accuracy. Data were pooled using a random-effects model. Main Outcomes and Measures: The primary outcome of interest was rate of modified Rankin Scale (mRS) scores of 0 to 2 at 90 days. Secondary outcomes of interest included rates of successful reperfusion, defined as thrombolysis in cerebral infarction (TICI) scores of 2b to 3, 90-day mortality, symptomatic intracranial hemorrhage (SICH), and baseline patient characteristics. Results: Of 1696 initially retrieved studies, 10 studies were included, with 6543 patients. Patients with AF were a mean of 10.17 (95% CI, 8.11-12.23) years older (P < .001) and had higher rates of hypertension (OR, 1.89 [95% CI, 1.57-2.27]; P < .001) and diabetes (OR, 1.16 [95% CI, 1.02-1.31]; P = .02). Overall, there were comparable rates of mRS scores of 0 to 2 between patients with AF and patients without AF (odds ratio [OR], 0.72 [95% CI, 0.47-1.10]; P = .13), with significant heterogeneity among the included studies. After sensitivity analysis, the rate of mRS scores of 0 to 2 was significantly lower among patients with AF (OR, 0.65 [95% CI, 0.52-0.81]; P < .001). Successful reperfusion rates were similar between the groups (OR, 1.11 [95% CI, 0.78-1.58]; P = .57). The rate of SICH was similar between groups (OR, 1.05 [95% CI, 0.84-1.31]; P = .68). Mortality was significantly higher in the AF group (OR, 1.47 [95% CI, 1.12-1.92]; P = .005). Conclusions and Relevance: In this systematic review and meta-analysis, patients with AF experienced worse 90-day outcomes, even in the setting of similar rates of successful reperfusion. This was likely associated with greater age and greater rates of comorbidities among patients with AF.","journal":"JAMA Network Open","year":2023,"id":321549,"datarank":1.7432953239572155,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":1.1756668788694764,"self_endowment_contribution":0.5676284450877392,"citer_contribution":1.1756668788694764,"corpus_percentile":87.98638508548001,"corpus_rank":1554,"citation_count":43,"citer_count":41,"citers_with_citation_signal":30,"citers_with_endowment":30,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5232,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":42255,"name":"Sherief Ghozy","orcid":"0000-0001-5629-3023","position":1,"is_corresponding":false},{"id":1033716,"name":"Trey Seymour","orcid":"0000-0002-1824-077X","position":2,"is_corresponding":false},{"id":1033717,"name":"Rishabh Gupta","orcid":"0000-0001-7656-5209","position":3,"is_corresponding":false},{"id":942878,"name":"Cem Bilgin","orcid":"0000-0003-1832-1278","position":4,"is_corresponding":false},{"id":424924,"name":"Ramanathan Kadirvel","orcid":"0000-0002-6786-9953","position":5,"is_corresponding":false},{"id":268243,"name":"Alejandro A. Rabinstein","orcid":"0000-0001-8359-2838","position":6,"is_corresponding":false},{"id":63663,"name":"David F. Kallmes","orcid":"0000-0002-8495-0040","position":7,"is_corresponding":false},{"id":942882,"name":"Hassan Kobeissi","orcid":"0000-0001-7446-624X","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36607633","pmcid":"PMC9857225","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}