{"doi":"10.1001/jamanetworkopen.2022.11967","title":"Association of Congenital and Acquired Cardiovascular Conditions With COVID-19 Severity Among Pediatric Patients in the US","abstract":"Importance: Identifying the associations between severe COVID-19 and individual cardiovascular conditions in pediatric patients may inform treatment. Objective: To assess the association between previous or preexisting cardiovascular conditions and severity of COVID-19 in pediatric patients. Design, Setting, and Participants: This retrospective cohort study used data from a large, multicenter, electronic health records database in the US. The cohort included patients aged 2 months to 17 years with a laboratory-confirmed diagnosis of COVID-19 or a diagnosis code indicating infection or exposure to SARS-CoV-2 at 85 health systems between March 1, 2020, and January 31, 2021. Exposures: Diagnoses for 26 cardiovascular conditions between January 1, 2015, and December 31, 2019 (before infection with SARS-CoV-2). Main Outcomes and Measures: The main outcome was severe COVID-19, defined as need for supplemental oxygen or in-hospital death. Mixed-effects, random intercept logistic regression modeling assessed the significance and magnitude of associations between 26 cardiovascular conditions and COVID-19 severity. Multiple comparison adjustment was performed using the Benjamini-Hochberg false discovery rate procedure. Results: The study comprised 171 416 pediatric patients; the median age was 8 years (IQR, 2-14 years), and 50.28% were male. Of these patients, 17 065 (9.96%) had severe COVID-19. The random intercept model showed that the following cardiovascular conditions were associated with severe COVID-19: cardiac arrest (odds ratio [OR], 9.92; 95% CI, 6.93-14.20), cardiogenic shock (OR, 3.07; 95% CI, 1.90-4.96), heart surgery (OR, 3.04; 95% CI, 2.26-4.08), cardiopulmonary disease (OR, 1.91; 95% CI, 1.56-2.34), heart failure (OR, 1.82; 95% CI, 1.46-2.26), hypotension (OR, 1.57; 95% CI, 1.38-1.79), nontraumatic cerebral hemorrhage (OR, 1.54; 95% CI, 1.24-1.91), pericarditis (OR, 1.50; 95% CI, 1.17-1.94), simple biventricular defects (OR, 1.45; 95% CI, 1.29-1.62), venous embolism and thrombosis (OR, 1.39; 95% CI, 1.11-1.73), other hypertensive disorders (OR, 1.34; 95% CI, 1.09-1.63), complex biventricular defects (OR, 1.33; 95% CI, 1.14-1.54), and essential primary hypertension (OR, 1.22; 95% CI, 1.08-1.38). Furthermore, 194 of 258 patients (75.19%) with a history of cardiac arrest were younger than 12 years. Conclusions and Relevance: The findings suggest that some previous or preexisting cardiovascular conditions are associated with increased severity of COVID-19 among pediatric patients in the US and that morbidity may be increased among individuals children younger than 12 years with previous cardiac arrest.","journal":"JAMA Network Open","year":2022,"id":251821,"datarank":0.7571523415992223,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.2743209678689922,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.2743209678689922,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":15,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6781,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":895248,"name":"Bradley J. Roth","orcid":"0000-0003-4321-9806","position":1,"is_corresponding":false},{"id":24122,"name":"Anita Patel","orcid":"0000-0002-3791-7379","position":2,"is_corresponding":false},{"id":533720,"name":"Olivia Heutlinger","orcid":"0000-0002-0850-9042","position":3,"is_corresponding":false},{"id":895769,"name":"Carly Heffernan","orcid":null,"position":4,"is_corresponding":false},{"id":342565,"name":"Antonio Arrieta","orcid":"0000-0001-9281-8915","position":5,"is_corresponding":false},{"id":345840,"name":"Terence D. Sanger","orcid":"0000-0002-1837-6044","position":6,"is_corresponding":false},{"id":38137,"name":"Dan M. Cooper","orcid":"0000-0003-4022-0043","position":7,"is_corresponding":false},{"id":466113,"name":"Babak Shahbaba","orcid":"0000-0002-8102-1609","position":8,"is_corresponding":false},{"id":895249,"name":"Anthony Chang","orcid":"0000-0003-4380-5151","position":9,"is_corresponding":false},{"id":412915,"name":"William Feaster","orcid":null,"position":10,"is_corresponding":false},{"id":895250,"name":"Sharief Taraman","orcid":"0000-0003-2108-2490","position":11,"is_corresponding":false},{"id":570163,"name":"Hiroki Morizono","orcid":"0000-0002-9678-5564","position":12,"is_corresponding":false},{"id":895251,"name":"Rachel Marano","orcid":"0000-0002-5924-3790","position":13,"is_corresponding":false},{"id":412083,"name":"Louis Ehwerhemuepha","orcid":"0000-0003-1369-7954","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:24:41.993282Z","pmid":"35579899","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}