{"doi":"10.1001/jamanetworkopen.2020.31669","title":"Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults","abstract":"Importance: The relationship of dietary niacin intake with the risk of hypertension remains unknown. Objective: To determine the prospective association between dietary niacin intake and new-onset hypertension, and examine factors that may modify the association among Chinese adults. Design, Setting, and Participants: This nationwide cohort study of 12 243 Chinese adults used dietary intake data from 7 rounds of the China Health and Nutrition Survey. Dietary intake was measured by 3 consecutive 24-hour dietary recalls from participants in combination with a weighing inventory taken over the same 3 days at the household level. Statistical analysis was conducted from May 2020 to August 2020. Exposures: Dietary intake. Main Outcomes and Measures: The study outcome was new-onset hypertension, defined as systolic blood pressure 140 mm Hg or greater and/or diastolic blood pressure 90 mm Hg or greater, diagnosis by physician, or current antihypertensive treatment during the follow-up. Results: The mean (SD) age of the study population was 41.2 (14.2) years, and 5728 (46.8%) of participants were men. The mean (SD) dietary niacin intake level was 14.8 (4.1) mg/d. A total of 4306 participants developed new-onset hypertension during a median (interquartile range) follow-up duration of 6.1 (3.6-11.3) years. When dietary niacin was assessed in quartiles, the lowest risk of new-onset hypertension was found in participants in quartile 3 (14.3 to <16.7 mg/d; adjusted hazard ratio, 0.83; 95% CI, 0.75-0.90) compared with those in quartile 1 (<12.4 mg/d). Consistently in the threshold analysis, for every 1 mg/d increase in dietary niacin, there was a 2% decrease in new-onset hypertension (adjusted HR, 0.98; 95% CI, 0.96-1.00) in those with dietary niacin intake less than 15.6 mg/d, and a 3% increase in new-onset hypertension (adjusted HR, 1.03; 95% CI, 1.02-1.04) in participants with dietary niacin 15.6 mg/d or greater. Based on these results, there was a J-shaped association between dietary niacin intake and new-onset hypertension in the general population of Chinese adults, with an inflection point at 15.6 mg/d and a minimal risk at 14.3 to 16.7 mg/d (quartile 3) of dietary niacin intake. Conclusions and Relevance: The results of this study provide some evidence for maintaining the optimal dietary niacin intake levels for the primary prevention of hypertension.","journal":"JAMA Network Open","year":2021,"id":153646,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7168,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320408,"name":"Mengyi Liu","orcid":"0000-0001-6605-9492","position":1,"is_corresponding":false},{"id":320409,"name":"Chun Zhou","orcid":"0009-0009-0575-4841","position":2,"is_corresponding":false},{"id":320411,"name":"Panpan He","orcid":"0000-0003-4238-5837","position":3,"is_corresponding":false},{"id":320412,"name":"Yuanyuan Zhang","orcid":"0000-0002-9894-248X","position":4,"is_corresponding":false},{"id":651575,"name":"Huan Li","orcid":"0000-0003-0662-6939","position":5,"is_corresponding":false},{"id":321925,"name":"Qinqin Li","orcid":null,"position":6,"is_corresponding":false},{"id":321926,"name":"Chengzhang Liu","orcid":null,"position":7,"is_corresponding":false},{"id":320414,"name":"Xianhui Qin","orcid":"0000-0001-7812-7982","position":8,"is_corresponding":false},{"id":320410,"name":"Zhuxian Zhang","orcid":"0000-0002-7504-0758","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:43:44.759273Z","pmid":"33404619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}