{"doi":"10.1001/jama.2025.3404","title":"Pediatric Gender Medicine—Reply","abstract":"Third, emerging evidence suggests that modulating glycosylation pathways could offer a novel therapeutic strategy for asthma management.Xie et al 5 proposed that targeting glycan recognition receptors, such as sialic acid-binding immunoglobulin-like lectins (siglecs) and galectins, may attenuate immune-driven airway inflammation.This raises a fundamental question: could inhibition of glycan recognition pathways modulate immune responses similarly to current biologic therapies that target IL-5 and IL-13 signaling pathways?Whether blocking glycan-mediated immune activation could provide comparable clinical benefits currently remains unexplored.Further research should investigate whether modulation of glycosylation-related enzymes (eg, fucosyltransferases and sialyltransferases) can regulate immune responses and serve as a novel intervention for asthma.","journal":"JAMA","year":2025,"id":552856,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1449177,"name":"Jilles Smids","orcid":"0000-0002-1259-0883","position":1,"is_corresponding":false},{"id":408597,"name":"John D. Lantos","orcid":"0000-0002-6553-3874","position":2,"is_corresponding":false},{"id":1449176,"name":"Moti Gorin","orcid":"0000-0003-1679-0118","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T02:54:37.527189Z","pmid":"40397440","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}