{"doi":"10.1001/jama.2023.9535","title":"Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19","abstract":"statin treatment in the treat-to-target group.While the effect of statin treatment on reducing clinical events is not solely caused by suppression of low-density lipoprotein cholesterol (LDL-C) level, and the authors adjusted for confounders, genetic factors such as apolipoprotein E gene polymorphisms may contribute to coronary artery disease and type 2 diabetes. 2,3 Individual variations in the response to statin treatment may be closely associated with genetic factors, and the recommendation of a treat-to-target LDL-C strategy for patients with cardiovascular disease should be made after understanding the magnitude of genetic contribution to the ability of LDL-C reduction and prevention of cardiovascular events.Additionally, this study included substantially more men (n = 3172) than women (n = 1228), and the authors did not comment on sex difference in this study. 1 The majority of women in this study were likely postmenopausal, and dyslipidemia increases over a woman's life span, with adverse changes occurring around menopause.","journal":"JAMA","year":2023,"id":388587,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":50840,"name":"Marcel Levi","orcid":"0000-0002-2212-5299","position":1,"is_corresponding":false},{"id":1158111,"name":"Bruce L. Davidson","orcid":"0000-0002-5886-7892","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T01:18:18.214733Z","pmid":"37526726","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}