{"doi":"10.1001/jama.2023.4899","title":"Screening for Latent Tuberculosis Infection in Adults","abstract":"<jats:sec id=\"ab-jus230005-1\"><jats:title>Importance</jats:title><jats:p>In the US, tuberculosis remains an important preventable disease, including active tuberculosis, which may be infectious, and latent tuberculosis infection (LTBI), which is asymptomatic and not infectious but can later progress to active disease. The precise prevalence rate of LTBI in the US is difficult to determine; however, estimated prevalence is about 5.0%, or up to 13 million persons. Incidence of tuberculosis varies by geography and living accommodations, suggesting an association with social determinants of health.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-2\"><jats:title>Objective</jats:title><jats:p>To update its 2016 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review on LTBI screening and treatment in asymptomatic adults seen in primary care, as well as the accuracy of LTBI screening tests.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-3\"><jats:title>Population</jats:title><jats:p>Asymptomatic adults 18 years or older at increased risk for tuberculosis.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-4\"><jats:title>Evidence Assessment</jats:title><jats:p>The USPSTF concludes with moderate certainty that there is a moderate net benefit in preventing active tuberculosis disease by screening for LTBI in persons at increased risk for tuberculosis infection.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-5\"><jats:title>Recommendation</jats:title><jats:p>The USPSTF recommends screening for LTBI in populations at increased risk. 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Incidence of tuberculosis varies by geography and living accommodations, suggesting an association with social determinants of health.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-2\"><jats:title>Objective</jats:title><jats:p>To update its 2016 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review on LTBI screening and treatment in asymptomatic adults seen in primary care, as well as the accuracy of LTBI screening tests.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-3\"><jats:title>Population</jats:title><jats:p>Asymptomatic adults 18 years or older at increased risk for tuberculosis.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-4\"><jats:title>Evidence Assessment</jats:title><jats:p>The USPSTF concludes with moderate certainty that there is a moderate net benefit in preventing active tuberculosis disease by screening for LTBI in persons at increased risk for tuberculosis infection.</jats:p></jats:sec><jats:sec id=\"ab-jus230005-5\"><jats:title>Recommendation</jats:title><jats:p>The USPSTF recommends screening for LTBI in populations at increased risk. 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