{"doi":"10.1001/jama.2020.1585","title":"Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China","abstract":"<h4>Importance</h4>In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.<h4>Objective</h4>To describe the epidemiological and clinical characteristics of NCIP.<h4>Design, setting, and participants</h4>Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020.<h4>Exposures</h4>Documented NCIP.<h4>Main outcomes and measures</h4>Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Outcomes of critically ill patients and noncritically ill patients were compared. Presumed hospital-related transmission was suspected if a cluster of health professionals or hospitalized patients in the same wards became infected and a possible source of infection could be tracked.<h4>Results</h4>Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men. Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]). Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). Lymphopenia (lymphocyte count, 0.8 × 109/L [interquartile range {IQR}, 0.6-1.1]) occurred in 97 patients (70.3%), prolonged prothrombin time (13.0 seconds [IQR, 12.3-13.7]) in 80 patients (58%), and elevated lactate dehydrogenase (261 U/L [IQR, 182-403]) in 55 patients (39.9%). Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients. Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). Thirty-six patients (26.1%) were transferred to the intensive care unit (ICU) because of complications, including acute respiratory distress syndrome (22 [61.1%]), arrhythmia (16 [44.4%]), and shock (11 [30.6%]). The median time from first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to ARDS was 8.0 days. Patients treated in the ICU (n = 36), compared with patients not treated in the ICU (n = 102), were older (median age, 66 years vs 51 years), were more likely to have underlying comorbidities (26 [72.2%] vs 38 [37.3%]), and were more likely to have dyspnea (23 [63.9%] vs 20 [19.6%]), and anorexia (24 [66.7%] vs 31 [30.4%]). Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). As of February 3, 47 patients (34.1%) were discharged and 6 died (overall mortality, 4.3%), but the remaining patients are still hospitalized. Among those discharged alive (n = 47), the median hospital stay was 10 days (IQR, 7.0-14.0).<h4>Conclusions and relevance</h4>In this single-center case series of 138 hospitalized patients with confirmed NCIP in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected in 41% of patients, 26% of patients received ICU care, and mortality was 4.3%.","journal":"JAMA","year":2020,"id":6354,"datarank":46.032604126905014,"base_score":9.959253330441985,"endowment":9.959253330441985,"self_citation_contribution":1.493887999566298,"citation_network_contribution":44.538716127338716,"self_endowment_contribution":1.493887999566298,"citer_contribution":44.538716127338716,"corpus_percentile":100.0,"corpus_rank":322,"citation_count":21146,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-03-17","authors":[{"id":28313,"name":"Bo Hu","orcid":"0000-0003-0751-885X","position":1,"is_corresponding":false},{"id":58794,"name":"Chang Hu","orcid":null,"position":2,"is_corresponding":false},{"id":58795,"name":"Fangfang Zhu","orcid":null,"position":3,"is_corresponding":false},{"id":58796,"name":"Xing Liu","orcid":null,"position":4,"is_corresponding":false},{"id":13180,"name":"Jing Zhang","orcid":"0000-0002-5970-0509","position":5,"is_corresponding":false},{"id":666,"name":"Binbin Wang","orcid":"0000-0003-2885-6428","position":6,"is_corresponding":false},{"id":58797,"name":"Hui Xiang","orcid":null,"position":7,"is_corresponding":false},{"id":31755,"name":"Zhenshun Cheng","orcid":"0000-0002-7387-496X","position":8,"is_corresponding":false},{"id":58798,"name":"Yong Xiong","orcid":null,"position":9,"is_corresponding":false},{"id":58799,"name":"Yan Zhao","orcid":"0000-0002-1234-4455","position":10,"is_corresponding":false},{"id":58800,"name":"Yirong Li","orcid":null,"position":11,"is_corresponding":false},{"id":58801,"name":"Xinghuan Wang","orcid":null,"position":12,"is_corresponding":false},{"id":58802,"name":"Zhiyong Peng","orcid":null,"position":13,"is_corresponding":false},{"id":58793,"name":"Dawei Wang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}