{"doi":"10.1001/jama.2012.208831","title":"Emergence of Large Treatment Effects From Small Trials—Reply","abstract":"In Reply: We agree with Drs Batterham and Hopkins that small studies are not necessarily inherently flawed. However, probabilistically speaking, even in the absence of biases, small-sized trials are more prone to provide overestimates (or underestimates) compared with larger trials.","journal":"JAMA","year":2013,"id":7888,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0528,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2013-02-27","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":15114,"name":"Tiago V. Pereira","orcid":"0000-0002-8574-832X","position":1,"is_corresponding":false},{"id":15113,"name":"Ralph I. Horwitz","orcid":"0000-0002-1224-2723","position":2,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":0,"is_corresponding":true}],"reference_count":4,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}