{"doi":"10.1001/archpsyc.55.3.235","title":"Dorsal Striatal Size, Shape, and Metabolic Rate in Never-Medicated and Previously Medicated Schizophrenics Performing a Verbal Learning Task","abstract":null,"journal":"Archives of General Psychiatry","year":1998,"id":625586,"datarank":0.7574784010874307,"base_score":5.049856007249537,"endowment":5.049856007249537,"self_citation_contribution":0.7574784010874307,"citation_network_contribution":0.0,"self_endowment_contribution":0.7574784010874307,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1522099,"name":"Monte S. Buchsbaum","orcid":null,"position":1,"is_corresponding":false},{"id":952777,"name":"Erin A. Hazlett","orcid":null,"position":2,"is_corresponding":false},{"id":952778,"name":"M. Mehmet Haznedar","orcid":null,"position":3,"is_corresponding":false},{"id":178493,"name":"Philip D. Harvey","orcid":"0000-0002-9501-9366","position":4,"is_corresponding":false},{"id":1617971,"name":"Alan Newman","orcid":null,"position":5,"is_corresponding":false},{"id":1617972,"name":"David B. Schnur","orcid":null,"position":6,"is_corresponding":false},{"id":1617973,"name":"Jacqueline Spiegel-Cohen","orcid":null,"position":7,"is_corresponding":false},{"id":1617974,"name":"Tsechung Wei","orcid":null,"position":8,"is_corresponding":false},{"id":1617975,"name":"Josef Machac","orcid":null,"position":9,"is_corresponding":false},{"id":1617976,"name":"Karin Knesaurek","orcid":null,"position":10,"is_corresponding":false},{"id":354015,"name":"Shankar Vallabhajosula","orcid":"0000-0002-6638-3695","position":11,"is_corresponding":false},{"id":1617977,"name":"Melissa A. Biren","orcid":null,"position":12,"is_corresponding":false},{"id":1617978,"name":"Tina M. Ciaravolo","orcid":null,"position":13,"is_corresponding":false},{"id":1617979,"name":"Christina Luu-Hsia","orcid":null,"position":14,"is_corresponding":false},{"id":1617968,"name":"Lina Shihabuddin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dorsal Striatal Size, Shape, and Metabolic Rate in Never-Medicated and Previously Medicated Schizophrenics Performing a Verbal Learning Task","abstract":"BACKGROUND: Magnetic resonance imaging and positron emission tomography were used to study the size and metabolic rate of the caudate and the putamen in 18 patients with schizophrenia (n=16) or schizo-affective disorder (n=2) and 24 age- and sex-matched control subjects. METHODS: The patients were either never medicated (n=7) or drug free (n=11) for a median of 3 weeks. During uptake of fludeoxyglucose F 18, all patients performed a serial verbal learning test. Positron emission tomographic and magnetic resonance imaging scans were coregistered, and the caudate and the putamen were traced on the magnetic resonance image. RESULTS: The striatum had a significantly lower relative metabolic rate in schizophrenics than in controls. Never-medicated patients had lower metabolic rates in the right putamen (ventral part of the dorsal striatum) than previously medicated patients. The caudate was significantly smaller in never-medicated patients than in controls and largest in previously medicated patients. Patients with higher relative metabolic rates in the putamen scored higher on the Abnormal Involuntary Movements Scale. CONCLUSIONS: The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. Never-medicated patients, in contrast, had ventral striatal structures that were smaller and less active than those observed in controls and previously medicated patients.","is_dataset_classified":null,"base_score":5.049856007249537,"endowment":5.049856007249537,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9510217","pmcid":null,"openalex_id":"https://openalex.org/W2125272641","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"MH-40071","title":null}],"total_grants":1,"fwci":7.1239,"citation_percentile":0.9756731,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":5},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":3}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://jamanetwork.com/journals/jamapsychiatry/articlepdf/190978/yoa6123.pdf","host_type":"journal"},{"url":"https://jamanetwork.com/journals/jamapsychiatry/articlepdf/190978/yoa6123.pdf","host_type":"publisher"},{"url":"http://jamanetwork.com/journals/jamapsychiatry/fullarticle/190978","host_type":"publisher"},{"url":"https://doi.org/10.1001/archpsyc.55.3.235","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9510217","host_type":"repository"}],"fields_of_study":["Schizophrenia research and treatment","Neurological and metabolic disorders","Neurotransmitter Receptor Influence on Behavior"],"mesh_terms":["Adolescent","Adult","Caudate Nucleus","Corpus Striatum","Female","Glucose","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Putamen","Schizophrenia","Schizophrenic Psychology","Sex Factors","Tomography, Emission-Computed","Antipsychotic Agents","Verbal Learning","Fluorodeoxyglucose F18"],"keywords":["Putamen","Ventral striatum","Striatum","Magnetic resonance imaging","Positron emission tomography","Psychology","Schizophrenia (object-oriented programming)","Caudate nucleus","Functional magnetic resonance imaging","Internal medicine","Medicine","Neuroscience","Psychiatry","Radiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T07:11:02.049623Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}